Oral immunization against Helicobacter pylori--a future concept

Détails

ID Serval
serval:BIB_8B3CF5659206
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
Oral immunization against Helicobacter pylori--a future concept
Périodique
Journal of Gastroenterology
Auteur(s)
Michetti  P.
ISSN
0944-1174 (Print)
Statut éditorial
Publié
Date de publication
1998
Volume
33 Suppl 10
Pages
66-8
Notes
Journal Article
Review
Résumé
The demonstration that oral immunization with lysates of Helicobacter or with Helicobacter pylori urease can protect mice against H. felis infection opened the field of vaccine development against Helicobacter infections. More recently, the same antigen preparations were used successfully as a therapeutic vaccine able to cure the infection, and additional protective antigens were identified. Evidence from animal studies suggests that protection is medicated by mucosal antibodies, in association with a T helper type 2 cell cellular immune response. Vaccine adjuvants, delivery systems, and therapeutic vaccination are likely to be the areas of major progress in the future.
Mots-clé
Animals Antibodies, Bacterial/biosynthesis *Bacterial Vaccines/immunology Helicobacter Infections/*prevention & control Helicobacter pylori/*immunology Humans Urease/immunology
Pubmed
Web of science
Création de la notice
25/01/2008 17:02
Dernière modification de la notice
03/03/2018 19:11
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