Prevalence and timing of pregnancy termination for brain malformations.

Détails

ID Serval
serval:BIB_8ACE8EE09209
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Prevalence and timing of pregnancy termination for brain malformations.
Périodique
Archives of Disease In Childhood. Fetal and Neonatal Edition
Auteur(s)
Rouleau C., Gasner A., Bigi N., Couture A., Perez M.J., Blanchet P., Faure J.M., Rivier F., Boulot P., Laquerrière A., Encha-Razavi F.
ISSN
1468-2052 (Electronic)
ISSN-L
1359-2998
Statut éditorial
Publié
Date de publication
2011
Volume
96
Numéro
5
Pages
F360-F364
Langue
anglais
Résumé
Fourteen marmosets (Callithrix penicillata) were inoculated intradermally with promastigotes and/or amastigotes of Leishmania (Viannia) braziliensis (L. (V) b.) strains MHOM/BR/83/LTB-300 MHOM/BR/85/LTB-12 MHOM/BR/81/LTB-179 and MHOM/BR/82/LTB-250. The evolution of subsequent lesions was studied for 15 to 75 weeks post-inoculation (PI). All but 3 of the L. (V) b. injected marmosets developed a cutaneous lesion at the point of inoculation after 3 to 9 weeks, characterized by the appearance of subcutaneous nodules containing parasites. Parasites were isolated by culture (Difco Blood Agar) from all 11 positive animals. The maximum size of the lesions was variable and ranged between 37 mm2 to 107 mm2. Ulceration of primary nodules became evident after 3 to 12 weeks in all infected marmosets, but was faster and larger in 5 of the 11 animals. The active lesions persisted in 9 out of 11 Callithrix until the end of the observation period, which varied from 15-75 weeks. In 3 animals spontaneous healing of their lesions (13 to 25 weeks, PI) was observed but with cryptic parasitism. In another 2 infected animals there was regression followed by reactivation of the cutaneous lesions. The appearance of smaller satellite lesions adjacent to primary ones, as well as metastatic lesions to the ear lobes, were documented in 2 animals. Promastigotes of L. (Leishmania) amazonensis (L. (L) a.) MHOM/BR/77/LTB-16 were inoculated in 1 marmoset. This animal remained chronically infected for 6 months and the lesion developed in a similar manner to L. (V) b. infected marmosets. No significant differences in clinical and parasitological behaviour were observed between promastigote or amastigote derived infections of the 2 species.(ABSTRACT TRUNCATED AT 250 WORDS)
Mots-clé
Animals, Antibodies, Protozoan/analysis, Callithrix, Disease Models, Animal, Leishmania braziliensis/immunology, Leishmania braziliensis/physiology, Leishmaniasis, Cutaneous/immunology, Leishmaniasis, Cutaneous/parasitology
Pubmed
Création de la notice
30/09/2011 14:32
Dernière modification de la notice
03/03/2018 19:10
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