Prevalence of renal cell carcinoma in patients with ESRD pre-transplantation: a pathologic analysis

Détails

ID Serval
serval:BIB_8AB23A28BC1C
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Prevalence of renal cell carcinoma in patients with ESRD pre-transplantation: a pathologic analysis
Périodique
Kidney International
Auteur(s)
Denton  M. D., Magee  C. C., Ovuworie  C., Mauiyyedi  S., Pascual  M., Colvin  R. B., Cosimi  A. B., Tolkoff-Rubin  N.
ISSN
0085-2538
Statut éditorial
Publié
Date de publication
06/2002
Peer-reviewed
Oui
Volume
61
Numéro
6
Pages
2201-9
Notes
Journal Article --- Old month value: Jun
Résumé
BACKGROUND: Acquired renal cystic disease (ARCD), renal adenoma (AD), and renal cell carcinoma (RCC) are more common in patients with end-stage renal disease (ESRD). However, the prevalence of these conditions in patients undergoing transplantation, and the clinical characteristics associated with their occurrence are unclear. METHODS: At our institution, the majority of patients undergo an ipsilateral native nephrectomy at the time of transplantation, providing a unique opportunity to study the prevalence and pathology of ARCD, AD and RCC in ESRD. We retrospectively reviewed all consecutive nephrectomy pathology reports over a six year period. Demographic and clinical characteristics associated with these lesions were identified. RESULTS: Two hundred and sixty nephrectomy reports were reviewed: ARCD, AD, RCC and oncocytoma were found in 33%, 14%, 4.2% and 0.6% of cases, respectively. On multivariable analysis, ARCD was positively associated with male sex and longer dialysis duration and negatively associated with peritoneal dialysis. Similarly, AD was positively associated with male sex, longer dialysis duration and greater age. There was a trend for RCC cases to share similar associations although the small total number of cases precluded findings of statistical significance. CONCLUSION: By pathologic analysis, renal tumors are more common in the pre-transplant ESRD population than previously reported (using radiologic methods). Our study also identifies risk factors for their occurrence. This may prove useful in designing screening studies for renal tumors in this patient population.
Mots-clé
Adenoma/etiology Carcinoma, Renal Cell/*epidemiology/*etiology/pathology Cysts/etiology Female Humans Kidney Diseases/etiology Kidney Failure, Chronic/*complications/*surgery/therapy Kidney Neoplasms/*epidemiology/*etiology/pathology *Kidney Transplantation Male Peritoneal Dialysis/adverse effects Prevalence Renal Dialysis Retrospective Studies Sex Distribution Time Factors
Pubmed
Web of science
Création de la notice
29/01/2008 14:52
Dernière modification de la notice
03/03/2018 19:10
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