Affective components and intensity of pain correlate with structural differences in gray matter in chronic back pain patients.

Détails

ID Serval
serval:BIB_8A8762AB99B8
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Affective components and intensity of pain correlate with structural differences in gray matter in chronic back pain patients.
Périodique
Pain
Auteur(s)
Schmidt-Wilcke T., Leinisch E., Gänssbauer S., Draganski B., Bogdahn U., Altmeppen J., May A.
ISSN
1872-6623 (Electronic)
ISSN-L
0304-3959
Statut éditorial
Publié
Date de publication
2006
Peer-reviewed
Oui
Volume
125
Numéro
1-2
Pages
89-97
Langue
anglais
Notes
Publication types: Controlled Clinical Trial ; Journal Article ; Research Support, Non-U.S. Gov't
Résumé
Although chronic back pain is one of the most frequent reasons for permanent impairment in people under 65, the neurobiological mechanisms of chronification remain vague. Evidence suggests that cortical reorganisation, so-called functional plasticity, may play a role in chronic back pain patients. In the search for the structural counterpart of such functional changes in the CNS, we examined 18 patients suffering from chronic back pain with voxel-based morphometry and compared them to 18 sex and age matched healthy controls. We found a significant decrease of gray matter in the brainstem and the somatosensory cortex. Correlation analysis of pain unpleasantness and the intensity of pain on the day of scanning revealed a strong negative correlation (i.e. a decrease in gray matter with increasing unpleasantness/increasing intensity of pain) in these areas. Additionally, we found a significant increase in gray matter bilaterally in the basal ganglia and the left thalamus. These data support the hypothesis that ongoing nociception is associated with cortical and subcortical reorganisation on a structural level, which may play an important role in the process of the chronification of pain.
Mots-clé
Adult, Affect, Back Pain/diagnosis, Back Pain/pathology, Brain/pathology, Chronic Disease, Female, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Neurons/pathology, Pain Measurement, Statistics as Topic
Pubmed
Web of science
Création de la notice
18/01/2013 18:55
Dernière modification de la notice
20/08/2019 15:49
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