How best to fight that nasty itch - from new insights into the neuroimmunological, neuroendocrine, and neurophysiological bases of pruritus to novel therapeutic approaches

Détails

ID Serval
serval:BIB_8A0580A5DEF0
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
How best to fight that nasty itch - from new insights into the neuroimmunological, neuroendocrine, and neurophysiological bases of pruritus to novel therapeutic approaches
Périodique
Experimental Dermatology
Auteur(s)
Biro  T., Ko  M. C., Bromm  B., Wei  E. T., Bigliardi  P., Siebenhaar  F., Hashizume  H., Misery  L., Bergasa  N. V., Kamei  C., Schouenborg  J., Roostermann  D., Szabo  T., Maurer  M., Bigliardi-Qi  M., Meingassner  J. G., Hossen  M. A., Schmelz  M., Steinhoff  M.
ISSN
0906-6705 (Print)
Statut éditorial
Publié
Date de publication
03/2005
Volume
14
Numéro
3
Pages
225-40
Notes
Journal Article --- Old month value: Mar
Résumé
While the enormous clinical and psychosocial importance of pruritus in many areas of medicine and the detrimental effects of chronic 'itch' on the quality of life of an affected individual are widely appreciated, the complexity of this sensation is still often grossly underestimated. The current Controversies feature highlights this complexity by portraying pruritus as a truly interdisciplinary problem at the crossroads of neurophysiology, neuroimmunology, neuropharmacology, protease research, internal medicine, and dermatology, which is combated most successfully if one keeps the multilayered nature of 'itch' in mind and adopts a holistic treatment approach - beyond the customary, frequently frustrane monotherapy with histamine receptor antagonists. In view of the often unsatisfactory, unidimensional, and altogether rather crude standard instruments for pruritus management that we still tend to use in clinical practice today, an interdisciplinary team of pruritus experts here critically examines recent progress in pruritus research that future itch management must take into consideration. Focusing on new insights into the neuroimmunological, neuroendocrine, and neurophysiological bases of pruritus, and discussing available neuropharmacological tools, specific research avenues are highlighted, whose pursuit promises to lead to novel, and hopefully more effective, forms of pruritus management.
Mots-clé
Dermatology/*trends Humans Immune System/*physiopathology Nervous System/*physiopathology Neurosecretory Systems/*physiopathology Pruritus/*physiopathology/*therapy
Pubmed
Web of science
Création de la notice
25/01/2008 17:30
Dernière modification de la notice
03/03/2018 19:08
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