The hormonal control of endometrial receptivity: estrogen (E2) and progesterone

Détails

ID Serval
serval:BIB_89FA150780BE
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
The hormonal control of endometrial receptivity: estrogen (E2) and progesterone
Périodique
Journal of Reproductive Immunology
Auteur(s)
de Ziegler  D., Fanchin  R., de Moustier  B., Bulletti  C.
ISSN
0165-0378
Statut éditorial
Publié
Date de publication
08/1998
Peer-reviewed
Oui
Volume
39
Numéro
1-2
Pages
149-66
Notes
Journal Article
Review --- Old month value: Aug
Résumé
While the number of identified substances produced by the ovary increases steadily, it remains remarkable that the sole use of exogenous estrogen (E2) and progesterone (P) can prime optimal endometrial receptivity in women whose ovaries have failed or are absent. Early work showed that a marked leeway existed in the acceptable duration of the E2-only phase of endometrial priming. Subsequently, a sequence of transformations are induced by exogenous progesterone that reproduces classical findings made in the menstrual cycle. Secretory changes in endometrial glands are best seen between the 4th and 6th day of progesterone administration (day 18-20 of an ideal cycle where progesterone exposure starts on day 15). Predecidual changes of the endometrial stroma are apparent starting on the 10th day of progesterone exposure (day 24). Contrary to earlier belief, even maximal alterations in the plasma E2 to progesterone ratio fails to alter the endometrial morphology of either glands or stroma. More recently it has been recognized that E2 and progesterone also affect uterine contractility. It has been postulated that excessively high levels of E2 may increase uterine contractility and adversely affect implantation rates in in-vitro fertilization (IVF). Exogenous progesterone has been shown to exert utero-relaxing effects and it has been hypothesised that progesterone supplementation before embryo transfer (ET) may improve receptivity in IVF.
Mots-clé
Androgens/blood Animals Endometrium/*drug effects Estradiol/*pharmacology Female Fertilization in Vitro Humans Progesterone/blood/*pharmacology Uterine Contraction/drug effects
Pubmed
Web of science
Création de la notice
28/02/2008 12:37
Dernière modification de la notice
03/03/2018 19:08
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