Article: article from journal or magazin.
Phénytoine et test du ganglion poplité chez le rat Sprague Dawley [Phenytoin and the popliteal lymph node test in the Sprague-Dawley rat].
Journal De Toxicologie Clinique et Expérimentale
Publication types: English Abstract ; Journal ArticlePublication Status: ppublish
The detection of xenobiotics which the potential to induce autoimmune reactions is currently hardly possible. The popliteal lymph node assay initially developed in mice may prove useful in this regard. Results obtained with phenytoin in Sprague Dawley rats are presented. Single doses of phenytoin were injected into one hind footpad and the popliteal lymph node was excised and weighed 3, 7 or 10 days after injection. Only the 5 mg dose level produced a significant increase in popliteal lymph node weight, structural and cellular changes in the lymph node indicating a humoral stimulation was noticed in the males at 2 mg and in the males and females at 5 mg. These results warrant further progress in the development of this assay.
Animals, Autoimmune Diseases/chemically induced, Autoimmune Diseases/diagnosis, Female, Lymph Nodes/cytology, Lymph Nodes/drug effects, Male, Phenytoin/toxicity, Rats, Rats, Inbred Strains
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