Architectural and Functional Similarities between Trimeric ATP-Gated P2X Receptors and Acid-Sensing Ion Channels

Détails

Ressource 1Télécharger: BIB_8983C9F71E90.P001.pdf (6856.60 [Ko])
Etat: Public
Version: Author's accepted manuscript
ID Serval
serval:BIB_8983C9F71E90
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
Architectural and Functional Similarities between Trimeric ATP-Gated P2X Receptors and Acid-Sensing Ion Channels
Périodique
Journal of Molecular Biology
Auteur(s)
Kellenberger S., Grutter T.
ISSN
0022-2836
Statut éditorial
Publié
Date de publication
2015
Peer-reviewed
Oui
Volume
427
Numéro
1
Pages
54-66
Langue
anglais
Notes
Review
Résumé
ATP-gated P2X receptors and acid-sensing ion channels are two distinct ligand-gated ion channels that assemble into trimers. They are involved in many important physiological functions such as pain sensation and are recognized as important therapeutic targets. They have unrelated primary structures and respond to different ligands (ATP and protons) and are thus considered as two different ion channels. As a consequence, comparisons of the biophysical properties and underlying mechanisms have only been rarely made between these two channels. However, the recent determination of their molecular structures by X-ray crystallography has revealed unexpected parallels in the architecture of the two pores, providing a basis for possible functional analogies. In this review, we analyze the structural and functional similarities that are shared by these trimeric ion channels, and we outline key unanswered questions that, if addressed experimentally, may help us to elucidate how two unrelated ion channels have adopted a similar fold of the pore.
Pubmed
Web of science
Création de la notice
11/07/2014 7:11
Dernière modification de la notice
20/08/2019 14:48
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