Associated factors in the prevalence of more than 50 common melanocytic nevi, atypical melanocytic nevi, and actinic lentigines: multicenter case-control study of the Central Malignant Melanoma Registry of the German Dermatological Society

Détails

ID Serval
serval:BIB_88FAD7888E80
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Associated factors in the prevalence of more than 50 common melanocytic nevi, atypical melanocytic nevi, and actinic lentigines: multicenter case-control study of the Central Malignant Melanoma Registry of the German Dermatological Society
Périodique
Journal of Investigative Dermatology
Auteur(s)
Garbe  C., Buttner  P., Weiss  J., Soyer  H. P., Stocker  U., Kruger  S., Roser  M., Weckbecker  J., Panizzon  R., Bahmer  F., Tilgen  W., Guggenmooscholzmann  I., Orfanos  C. E.
ISSN
0022-202X (Print)
Statut éditorial
Publié
Date de publication
05/1994
Volume
102
Numéro
5
Pages
700-5
Notes
Journal Article Research Support, Non-U.S. Gov't --- Old month value: May
Résumé
Several case-control studies identified common and atypical melanocytic nevi as major risk indicators for the development of cutaneous melanoma. The present investigation was planned to detect factors associated with the prevalence of these melanoma risk markers. Whole-body examination findings and interview data of 513 melanoma patients and 498 age- and sex-matched control subjects were analyzed. Existence of more than 50 common melanocytic nevi and the presence of atypical melanocytic nevi were significantly related to age and gender, with significantly elevated relative risk for their prevalence before the age of 60 and in males. Additionally, sunburns before the age of 20 were significantly associated with both more than 50 common melanocytic nevi (relative risk = 1.7) and the presence of atypical melanocytic nevi (relative risk = 1.5). Actinic lentigines were found more frequently with increasing age, and the presence of actinic lentigines was significantly related to a tendency of freckling in adolescence (relative risk = 2.0) and to two or more sunburns after the age of 20 (relative risk = 1.6). In conclusion, sunburns before the age of 20 contribute to the development of multiple melanocytic nevi and atypical melanocytic nevi. In adulthood, this type of sun exposure is associated with the development of actinic lentigines. The relative risk of developing cutaneous melanoma increases in association with the development of these benign melanocytic lesions.
Mots-clé
Adolescent Adult Aged Case-Control Studies Female Hair Color Humans Lentigo/*epidemiology Male Melanoma/etiology Melanosis/epidemiology Middle Aged Multicenter Studies Nevus, Pigmented/*epidemiology Prevalence Skin/pathology Skin Neoplasms/etiology
Pubmed
Web of science
Open Access
Oui
Création de la notice
25/01/2008 16:54
Dernière modification de la notice
20/08/2019 14:48
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