The winged-helix transcription factor Trident is expressed in actively dividing lymphocytes.

Détails

ID Serval
serval:BIB_88E0858A93EF
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
The winged-helix transcription factor Trident is expressed in actively dividing lymphocytes.
Périodique
Immunobiology
Auteur(s)
Korver W., Roose J., Wilson A., Clevers H.
ISSN
0171-2985 (Print)
ISSN-L
0171-2985
Statut éditorial
Publié
Date de publication
1997
Volume
198
Numéro
1-3
Pages
157-161
Langue
anglais
Résumé
We recently identified the winged-helix transcription factor Trident and described its expression pattern in synchronized fibroblasts. We have now studied Trident expression in cell lines, differentiating thymocytes and in lymphocytes derived from peripheral blood. During T cell differentiation, expression peaked in the actively dividing immature single positive cells. In peripheral blood lymphocytes, expression of Trident mRNA was absent, but could be induced upon stimulation with mitogens in vitro. These observations imply a function for Trident in dividing lymphocytes.
Mots-clé
Cell Cycle, Cell Differentiation, Cell Line, Forkhead Transcription Factors, Humans, T-Lymphocytes/cytology, T-Lymphocytes/metabolism, Thymus Gland/cytology, Transcription Factors/biosynthesis, Transcription Factors/genetics, Tumor Cells, Cultured
Pubmed
Web of science
Création de la notice
11/04/2013 10:54
Dernière modification de la notice
20/08/2019 14:47
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