Elevated serum uric acid is associated with high circulating inflammatory cytokines in the population-based Colaus study.

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Etat: Public
Version: Final published version
ID Serval
serval:BIB_8854BDE329EF
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Elevated serum uric acid is associated with high circulating inflammatory cytokines in the population-based Colaus study.
Périodique
Plos One
Auteur(s)
Lyngdoh Tanica, Marques-Vidal Pedro, Paccaud Fred, Preisig Martin, Waeber Gérard, Bochud Murielle, Vollenweider Peter
ISSN
1932-6203 (Electronic)
ISSN-L
1932-6203
Statut éditorial
Publié
Date de publication
2011
Peer-reviewed
Oui
Volume
6
Numéro
5
Pages
e19901
Langue
anglais
Résumé
BACKGROUND: The relation of serum uric acid (SUA) with systemic inflammation has been little explored in humans and results have been inconsistent. We analyzed the association between SUA and circulating levels of interleukin-6 (IL-6), interleukin-1beta (IL-1beta), tumor necrosis factor- alpha (TNF-alpha) and C-reactive protein (CRP). METHODS AND FINDINGS: This cross-sectional population-based study conducted in Lausanne, Switzerland, included 6085 participants aged 35 to 75 years. SUA was measured using uricase-PAP method. Plasma TNF-alpha, IL-1beta and IL-6 were measured by a multiplexed particle-based flow cytometric assay and hs-CRP by an immunometric assay. The median levels of SUA, IL-6, TNF-alpha, CRP and IL-1beta were 355 micromol/L, 1.46 pg/mL, 3.04 pg/mL, 1.2 mg/L and 0.34 pg/mL in men and 262 micromol/L, 1.21 pg/mL, 2.74 pg/mL, 1.3 mg/L and 0.45 pg/mL in women, respectively. SUA correlated positively with IL-6, TNF-alpha and CRP and negatively with IL-1beta (Spearman r: 0.04, 0.07, 0.20 and 0.05 in men, and 0.09, 0.13, 0.30 and 0.07 in women, respectively, P<0.05). In multivariable analyses, SUA was associated positively with CRP (beta coefficient +/- SE = 0.35+/-0.02, P<0.001), TNF-alpha (0.08+/-0.02, P<0.001) and IL-6 (0.10+/-0.03, P<0.001), and negatively with IL-1beta (-0.07+/-0.03, P = 0.027). Upon further adjustment for body mass index, these associations were substantially attenuated. CONCLUSIONS: SUA was associated positively with IL-6, CRP and TNF-alpha and negatively with IL-1beta, particularly in women. These results suggest that uric acid contributes to systemic inflammation in humans and are in line with experimental data showing that uric acid triggers sterile inflammation.
Mots-clé
Adult, Aged, C-Reactive Protein/metabolism, Cross-Sectional Studies, Cytokines/blood, Female, Flow Cytometry, Humans, Inflammation/blood, Inflammation/epidemiology, Interleukin-1beta/blood, Interleukin-6/blood, Male, Middle Aged, Switzerland/epidemiology, Tumor Necrosis Factor-alpha/blood, Uric Acid/blood, Colaus Study
Pubmed
Web of science
Open Access
Oui
Création de la notice
01/06/2011 14:55
Dernière modification de la notice
20/08/2019 15:47
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