Impact of quorum sensing on fitness of Pseudomonas aeruginosa.

Details

Serval ID
serval:BIB_87913346E16C
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Impact of quorum sensing on fitness of Pseudomonas aeruginosa.
Journal
International Journal of Medical Microbiology
Author(s)
Heurlier K., Dénervaud V., Haas D.
ISSN
1438-4221[print], 1438-4221[linking]
Publication state
Published
Issued date
2006
Volume
296
Number
2-3
Pages
93-102
Language
english
Abstract
In Pseudomonas aeruginosa, cell-cell communication based on N-acyl-homoserine lactone (AHL) signal molecules (termed quorum sensing) is known to control the production of extracellular virulence factors. Hence, in pathogenic interactions with host organisms, the quorum-sensing (QS) machinery can confer a selective advantage on P. aeruginosa. However, as shown by transcriptomic and proteomic studies, many intracellular metabolic functions are also regulated by quorum sensing. Some of these serve to regenerate the AHL precursors methionine and S-adenosyl-methionine and to degrade adenosine via inosine and hypoxanthine. The fact that a significant percentage of clinical and environmental isolates of P. aeruginosa is defective for QS because of mutation in the major QS regulatory gene lasR, raises the question of whether the QS machinery can have a negative impact on the organism's fitness. In vitro, lasR mutants have a higher probability to escape lytic death in stationary phase under alkaline conditions than has the QS-proficient wild type. Similar selective forces might also operate in natural environments.
Keywords
4-Butyrolactone/analogs & derivatives, 4-Butyrolactone/physiology, Bacterial Proteins/genetics, Cell Communication, DNA-Binding Proteins/genetics, Deoxyadenosines/metabolism, Humans, Pseudomonas Infections/microbiology, Pseudomonas aeruginosa/genetics, Pseudomonas aeruginosa/pathogenicity, Thionucleosides/metabolism, Trans-Activators/genetics, Virulence
Pubmed
Web of science
Create date
25/01/2008 17:01
Last modification date
20/08/2019 14:46
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