HLA-C cell surface expression and control of HIV/AIDS correlate with a variant upstream of HLA-C.

Détails

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Etat: Serval
Version: de l'auteur
ID Serval
serval:BIB_877586039537
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
HLA-C cell surface expression and control of HIV/AIDS correlate with a variant upstream of HLA-C.
Périodique
Nature Genetics
Auteur(s)
Thomas Rasmi, Apps Richard, Qi Ying, Gao Xiaojiang, Male Victoria, O'hUigin Colm, O'Connor Geraldine, Ge Dongliang, Fellay Jacques, Martin Jeffrey N., Margolick Joseph, Goedert James J., Buchbinder Susan, Kirk Gregory D., Martin Maureen P., Telenti Amalio, Deeks Steven G., Walker Bruce D., Goldstein David, McVicar Daniel W., Moffett Ashley, Carrington Mary
ISSN
1546-1718[electronic]
Statut éditorial
Publié
Date de publication
2009
Peer-reviewed
Oui
Volume
41
Numéro
12
Pages
1290-1294
Langue
anglais
Résumé
A variant 35 kb upstream of the HLA-C gene (-35C/T) was previously shown to associate with HLA-C mRNA expression level and steady-state plasma HIV RNA levels. We genotyped this variant in 1,698 patients of European ancestry with HIV. Individuals with known seroconversion dates were used for disease progression analysis and those with longitudinal viral load data were used for viral load analysis. We further tested cell surface expression of HLA-C in normal donors using an HLA-C-specific antibody. We show that the -35C allele is a proxy for high HLA-C cell surface expression, and that individuals with high-expressing HLA-C alleles progress more slowly to AIDS and control viremia significantly better than individuals with low HLA-C expressing alleles. These data strongly implicate high HLA-C expression levels in more effective control of HIV-1, potentially through better antigen presentation to cytotoxic T lymphocytes or recognition and killing of infected cells by natural killer cells.
Mots-clé
Immunodeficiency-Virus Type-1, Natural-Killer-Cells, Class-I Molecules, Mhc Class-I, Single Amino-Acid, HIV-1 Infection, Monoclonal-Antibodies, Inhibitory Receptors, Trophoblast Cells, AIDS
Pubmed
Web of science
Création de la notice
15/12/2009 15:20
Dernière modification de la notice
03/03/2018 19:02
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