New approaches in metastatic melanoma: biological and molecular targeted therapies
Details
Serval ID
serval:BIB_863EEE4CB3D9
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
New approaches in metastatic melanoma: biological and molecular targeted therapies
Journal
Expert Review of Anticancer Therapy
ISSN
1473-7140 (Print)
Publication state
Published
Issued date
05/2007
Volume
7
Number
5
Pages
701-13
Notes
Journal Article
Review --- Old month value: May
Review --- Old month value: May
Abstract
Classical metastatic melanoma therapy is disappointing but important progress has been made in the understanding of melanoma biology. Genetic lesions and several intracellular signaling pathways that could serve as targets for novel therapy have been identified and a number of new agents are under evaluation. Promising tumor cell targets were identified in the cell membrane, cytoplasm and nucleus. New therapeutic approaches, besides monoclonal antibodies and vaccination, include an increasing number of small molecules that have been shown to interfere restrictively with intracellular signaling pathways in melanoma and decrease proliferation, survival, migration or invasion. Other agents can interfere with stromal components of melanoma, such as angiogenesis and components of the immune system.
Keywords
Angiogenesis Inhibitors/*therapeutic use
Antineoplastic Agents/*therapeutic use
Cancer Vaccines/therapeutic use
Gene Therapy
Humans
*Immunotherapy
Melanoma/blood supply/secondary/*therapy
Receptor Protein-Tyrosine Kinases/antagonists & inhibitors
Signal Transduction/*drug effects
Skin Neoplasms/pathology
Tumor Necrosis Factor-alpha/therapeutic use
Pubmed
Web of science
Create date
28/01/2008 12:33
Last modification date
20/08/2019 15:45