Notch regulation of lymphocyte development and function.

Details

Serval ID
serval:BIB_8616361FC25B
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Notch regulation of lymphocyte development and function.
Journal
Nature Immunology
Author(s)
Radtke F., Wilson A., Mancini S.J., MacDonald H.R.
ISSN
1529-2908 (Print)
ISSN-L
1529-2908
Publication state
Published
Issued date
2004
Peer-reviewed
Oui
Volume
5
Number
3
Pages
247-253
Language
english
Abstract
Notch proteins regulate a broad spectrum of cell fate decisions and differentiation processes during fetal and postnatal development. Mammals have four Notch receptors that bind five different ligands. The function of Notch signaling during lymphopoiesis and T cell neoplasia, based on gain-of-function and conditional loss-of-function approaches for the Notch1 receptor, indicates Notch1 is essential in T cell lineage commitment. Recent studies have addressed the involvement of other Notch receptors and ligands as well as their downstream targets, demonstrating additional functions of Notch signaling in embryonic hematopoiesis, intrathymic T cell development, B cell development and peripheral T cell function.
Keywords
Animals, B-Lymphocytes/immunology, Cell Lineage, Hematopoiesis, Hematopoietic Stem Cells/physiology, Humans, Leukemia, T-Cell/immunology, Lymphopoiesis, Membrane Proteins/physiology, Mice, Receptors, Notch, Signal Transduction, T-Lymphocytes/immunology, Thymus Gland/cytology, Thymus Gland/immunology
Pubmed
Web of science
Create date
28/01/2008 11:39
Last modification date
20/08/2019 14:45
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