Notch regulation of lymphocyte development and function.

Détails

ID Serval
serval:BIB_8616361FC25B
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
Notch regulation of lymphocyte development and function.
Périodique
Nature Immunology
Auteur(s)
Radtke F., Wilson A., Mancini S.J., MacDonald H.R.
ISSN
1529-2908 (Print)
ISSN-L
1529-2908
Statut éditorial
Publié
Date de publication
2004
Peer-reviewed
Oui
Volume
5
Numéro
3
Pages
247-253
Langue
anglais
Résumé
Notch proteins regulate a broad spectrum of cell fate decisions and differentiation processes during fetal and postnatal development. Mammals have four Notch receptors that bind five different ligands. The function of Notch signaling during lymphopoiesis and T cell neoplasia, based on gain-of-function and conditional loss-of-function approaches for the Notch1 receptor, indicates Notch1 is essential in T cell lineage commitment. Recent studies have addressed the involvement of other Notch receptors and ligands as well as their downstream targets, demonstrating additional functions of Notch signaling in embryonic hematopoiesis, intrathymic T cell development, B cell development and peripheral T cell function.
Mots-clé
Animals, B-Lymphocytes/immunology, Cell Lineage, Hematopoiesis, Hematopoietic Stem Cells/physiology, Humans, Leukemia, T-Cell/immunology, Lymphopoiesis, Membrane Proteins/physiology, Mice, Receptors, Notch, Signal Transduction, T-Lymphocytes/immunology, Thymus Gland/cytology, Thymus Gland/immunology
Pubmed
Web of science
Création de la notice
28/01/2008 11:39
Dernière modification de la notice
20/08/2019 14:45
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