Consequences of vascular flow on lung injury induced by mechanical ventilation.

Détails

ID Serval
serval:BIB_8524
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Consequences of vascular flow on lung injury induced by mechanical ventilation.
Périodique
American Journal of Respiratory and Critical Care Medicine
Auteur(s)
Broccard A.F., Hotchkiss J.R., Kuwayama N., Olson D.A., Jamal S., Wangensteen D.O., Marini J.J.
ISSN
1073-449X
Statut éditorial
Publié
Date de publication
1998
Volume
157
Numéro
6 Pt 1
Pages
1935-1942
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, P.H.S. Publication Status: ppublish
Résumé
To investigate whether the magnitude of blood flow contributes to ventilator-induced lung injury, 14 sets of isolated rabbit lungs were randomized for perfusion at either 300 (Group A: n = 7) or 900 ml/ min (Group B: n = 7) while ventilated with 30 cm H2O peak static pressure. Control lungs (Group C: n = 7) were ventilated with lower peak static pressure (15 cm H2O) and perfused at 500 ml/min. Weight gain, changes in the ultrafiltration coefficient (DeltaKf) and lung static compliance (CL), and extent of hemorrhage (scored by histology) were compared. Group B had a larger decrease in CL (-13 +/- 11%) than Groups A (2 +/- 6%) and C (5 +/- 5%) (p < 0.05). Group B had more hemorrhage and gained more weight (16.2 +/- 9.5 g) than Groups A (8.7 +/- 3.4 g) and C (1.6 +/- 1.0 g) (p < 0.05 for each pairwise comparison between groups). Finally, Kf (g . min-1 . cm H2O-1 . 100 g-1) increased the most in Group B (DeltaKf = 0.26 +/- 0. 20 versus 0.17 +/- 0.10 in Group A and 0.05 +/- 0.04 in Group C; p < 0.05 for B versus C). We conclude that the intensity of lung perfusion contributes to ventilator- induced lung injury in this model.
Mots-clé
Animals, Blood Pressure, Hemodynamics, Hemorrhage/etiology, Hemorrhage/pathology, Lung/pathology, Organ Size, Positive-Pressure Respiration, Intrinsic, Pulmonary Circulation, Rabbits, Respiration, Artificial/adverse effects, Respiratory Distress Syndrome, Adult/etiology, Respiratory Distress Syndrome, Adult/pathology
Pubmed
Web of science
Création de la notice
19/11/2007 13:46
Dernière modification de la notice
03/03/2018 18:56
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