Systemic biomarkers in exacerbations of COPD: the evolving clinical challenge.

Details

Serval ID
serval:BIB_84F88910EE32
Type
Article: article from journal or magazin.
Collection
Publications
Title
Systemic biomarkers in exacerbations of COPD: the evolving clinical challenge.
Journal
Chest
Author(s)
Koutsokera A., Stolz D., Loukides S., Kostikas K.
ISSN
1931-3543 (Electronic)
ISSN-L
0012-3692
Publication state
Published
Issued date
02/2012
Peer-reviewed
Oui
Volume
141
Number
2
Pages
396-405
Language
english
Notes
Publication types: Journal Article ; Review
Publication Status: ppublish
Abstract
Exacerbations of COPD (ECOPD) remain a major cause of mortality and morbidity. Despite advances in the understanding of their pathophysiology, their assessment relies primarily on clinical presentation, which can be variable and difficult to predict. A large number of biomarkers already have been assessed in this context, and some appear to be promising.
An online search for articles published until December 2010 was conducted using three terms for ECOPD, five terms for biomarkers, and five terms for the sampling method. Biomarkers were evaluated for their potential role in the establishment and confirmation of the diagnosis of ECOPD, the evaluation of etiology and severity, the prediction of prognosis, and the guidance of treatment decisions.
Several systemic biomarkers have been measured in the context of ECOPD, and most have been found to increase at ECOPD onset and to subside during the course of exacerbations. Correlations have been reported among these biomarkers, but direct associations with clinical variables have been more difficult to establish. Although there are several limitations yet to be addressed, some of the biomarkers, most notably C-reactive protein for the identification of an ECOPD and procalcitonin for antibiotic guidance, may provide clinically relevant information.
So far, no single biomarker has been able to gain wide acceptance, but some provide clinically useful information. The evaluation of such biomarkers in large decision-making studies is expected to become an area of intense investigation in the near future.
Keywords
Biomarkers/analysis, Disease Progression, Humans, Predictive Value of Tests, Prognosis, Pulmonary Disease, Chronic Obstructive/diagnosis, Pulmonary Disease, Chronic Obstructive/etiology, Pulmonary Disease, Chronic Obstructive/physiopathology, Risk, Severity of Illness Index
Pubmed
Web of science
Create date
19/07/2019 18:33
Last modification date
21/08/2019 5:32
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