Effect of dexfenfluramine on energy expenditure in man.

Details

Serval ID
serval:BIB_8499CCA34429
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Effect of dexfenfluramine on energy expenditure in man.
Journal
International Journal of Obesity and Related Metabolic Disorders
Author(s)
Schutz Y., Munger R., Dériaz O., Jéquier E.
ISSN
0307-0565 (Print)
ISSN-L
0307-0565
Publication state
Published
Issued date
1992
Volume
16 Suppl 3
Pages
S61-S66
Language
english
Abstract
A short review has been made of the experimental studies performed in man, in which the effect of dexfenfluramine (D-F) on resting energy expenditure has been explored. It appears that the extent to which D-F possesses thermogenic properties (in addition to its anorectic effect) still remains controversial. Some investigators found either no significant increase in energy expenditure in response to the drug or a moderate effect in post-absorptive and/or postprandial state. It may be reasonable to assume that the supplementary weight loss observed with D-F as compared to a placebo can be primarily attributed to its anorectic effect rather than to its putative thermogenic effect.
Keywords
Adult, Basal Metabolism/drug effects, Body Temperature Regulation/drug effects, Energy Metabolism/drug effects, Female, Fenfluramine/pharmacology, Fenfluramine/therapeutic use, Humans, Male, Obesity/drug therapy, Obesity/metabolism
Pubmed
Web of science
Create date
21/01/2008 13:07
Last modification date
20/08/2019 14:44
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