The yield of high-density electric source imaging in focal epilepsy

Details

Serval ID
serval:BIB_843D89457D61
Type
Inproceedings: an article in a conference proceedings.
Publication sub-type
Abstract (Abstract): shot summary in a article that contain essentials elements presented during a scientific conference, lecture or from a poster.
Collection
Publications
Institution
Title
The yield of high-density electric source imaging in focal epilepsy
Title of the conference
21st Meeting of the European Neurological Society
Author(s)
Seeck M., Brodbeck V., Spinelli L., Lascano A., Wissmeyer M., Vulliemoz S., Pollo C., Schaller K., Michel C.
Address
Lisbon, Portugal, May 28-31, 2011
ISBN
0340-5354
Publication state
Published
Issued date
2011
Peer-reviewed
Oui
Volume
258
Series
Journal of Neurology
Pages
223
Language
english
Notes
Publication type : Meeting Abstract
Abstract
Background: EEG is the cornerstone of epilepsy diagnostics and mandatory to determine the underlying epilepsy syndrome (e.g. focal vs idiopathic generalized). However, its potential as imaging tool is still underrecognized. In the present study, we aim to determine the prerequisites of maximal benefit of electric source imaging (ESI) to localize the irritative zone in patients with focal epilepsy. Methods: 150 patients suffering from focal epilepsy and with minimum 1 year post-operative follow-up were studied prospectively by reviewers blinded to the underlying diagnosis and outcome. We evaluated the influence of two important factors on sensitivity and specificity of ESI: the number of electrodes (low resolution, LR-ESI: \30 vs. high resolution, HR-ESI: 128-256 electrodes), and the use of individual MRI (i-MRI) vs. template MRI (t-MRI) as head model.Results: ESI had a sensitivity of 85% and a specificity of 87% when HR-ESI with i-MRI was used. Using LR-ESI, sensitivity decreased to 68%, or even 57% when only t-MRI was available. The sensitivity of HR-ESI/i-MRI compared favorably with those of MRI (76%), PET (69%) and ictal/interictal SPECT (64%).Interpretation: This study on a large patient group shows excellent sensitivity and specificity of ESI if 128 EEG channels or more are used for ESI and if the results are co-registered to the patient's individual MRI. Localization precision is as high as or even higher than established brain imaging techniques, providing excellent costeffectiveness in epilepsy evaluation. HR-ESI appears to be a valuable additional imaging tool, given that larger electrode arrays are easily and rapidly applied with modern EEG equipment and that structural MRI is nearly always available for these patients.
Keywords
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Web of science
Create date
25/05/2011 9:03
Last modification date
20/08/2019 14:43
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