Carbaxylosides of 4-ethyl-2-oxo-2H-benzopyran-7-yl as non-hydrolyzable, orally active venous antithrombotic agents.

Details

Request a copyRequest a copy
Serval ID
serval:BIB_8329
Type
Article: article from journal or magazin.
Collection
Publications
Institution
UNIL/CHUV
Title
Carbaxylosides of 4-ethyl-2-oxo-2H-benzopyran-7-yl as non-hydrolyzable, orally active venous antithrombotic agents.
Journal
Bioorganic & Medicinal Chemistry Letters
Author(s)
Jeanneret V., Vogel P., Renaut P., Millet J., Theveniaux J., Barberousse V.
ISSN
0960-894X
Publication state
Published
Issued date
1998
Volume
8
Number
13
Pages
1687-1688
Language
english
Notes
Publication types: Journal Article
Abstract
A (-)-conduritol F derivative was condensed with 4-ethyl-7-hydroxy-2H-1-benzopyran-2-one and converted into (+)-4-ethyl-7-[(1'R,2'S,3'S,4'R)-2',3',4'- trihydroxycyclohexyloxy]-2H-1-benzopyran-2-one ((+)-2). Enantiomer (-)-2 was obtained from a (+)-conduritol F derivative. The carbaxyloside (-)-2 with the L-xylose configuration was more active than (+)-2 in the Wessler's model.
Keywords
Administration, Oral, Anticoagulants/chemistry, Anticoagulants/pharmacology, Benzopyrans/chemistry, Benzopyrans/pharmacology, Hydrolysis, Thrombosis/drug therapy, Veins/pathology
OAI-PMH
oai:serval.unil.ch:BIB_8329
Pubmed
9873415
Create date
19/11/2007 11:37
Last modification date
20/08/2019 15:43
Usage data