Effects of angiotensin converting enzyme inhibition: a clinical point of view
Details
Serval ID
serval:BIB_83130E187F6D
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Effects of angiotensin converting enzyme inhibition: a clinical point of view
Journal
Journal of Cardiovascular Pharmacology
ISSN
0160-2446 (Print)
Publication state
Published
Issued date
1985
Volume
7 Suppl 4
Pages
S73-81
Notes
Journal Article
Review
Review
Abstract
Angiotensin converting enzyme inhibitors were developed to prevent the in vivo generation of angiotensin II and thereby to reduce peripheral vasoconstriction. However, these compounds exert some additional effects that may or may not be angiotensin dependent. These include potential sodium diuresis, bradykinin accumulation, prostaglandin release, blunting of sympathetic activity, parasympathomimetic actions, central effects, redistribution of blood flow toward some particularly important organs. Only the comprehensive assessment of the many complex interactions that exist between the renin-angiotensin and several other regulatory systems reveals the complete therapeutic profile of this class of pharmacologic agents.
Keywords
Angiotensin I/blood/physiology
Angiotensin II/blood/physiology
*Angiotensin-Converting Enzyme Inhibitors
Animals
Blood Circulation/drug effects
Blood Pressure/drug effects
Bradykinin/blood
Brain/drug effects
Heart Rate/drug effects
Humans
Hypertension/drug therapy/metabolism
Renin-Angiotensin System/drug effects
Sodium/metabolism
Pubmed
Web of science
Create date
05/03/2008 17:41
Last modification date
20/08/2019 15:43