Epithelial to mesenchymal transition in the pathogenesis of uterine malignant mixed Müllerian tumours: the role of ubiquitin proteasome system and therapeutic opportunities.

Détails

ID Serval
serval:BIB_81875B237845
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Epithelial to mesenchymal transition in the pathogenesis of uterine malignant mixed Müllerian tumours: the role of ubiquitin proteasome system and therapeutic opportunities.
Périodique
Clinical and Translational Oncology
Auteur(s)
Voutsadakis I.A.
ISSN
1699-3055 (Electronic)
ISSN-L
1699-048X
Statut éditorial
Publié
Date de publication
2012
Volume
14
Numéro
4
Pages
243-253
Langue
anglais
Notes
Publication types: Journal ArticlePublication Status: ppublish
Résumé
Malignant mixed Müllerian tumours (malignant mixed mesodermal tumours, MMMT) of the uterus are metaplastic carcinomas with a sarcomatous component and thus they are also called carcinosarcomas. It has now been accepted that the sarcomatous component is derived from epithelial elements that have undergone metaplasia. The process that produces this metaplasia is epithelial to mesenchymal transition (EMT), which has recently been described as a neoplasia-associated programme shared with embryonic development and enabling neoplastic cells to move and metastasise. The ubiquitin proteasome system (UPS) regulates the turnover and functions of hundreds of cellular proteins. It plays important roles in EMT by being involved in the regulation of several pathways participating in the execution of this metastasis-associated programme. In this review the specifi c role of UPS in EMT of MMMT is discussed and therapeutic opportunities from UPS manipulations are proposed.
Pubmed
Web of science
Création de la notice
12/05/2012 10:05
Dernière modification de la notice
20/08/2019 15:41
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