Exercise test in muscle channelopathies and other muscle disorders

Détails

ID Serval
serval:BIB_817410BEB441
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Exercise test in muscle channelopathies and other muscle disorders
Périodique
Muscle and Nerve
Auteur(s)
Kuntzer  T., Flocard  F., Vial  C., Kohler  A., Magistris  M., Labarre-Vila  A., Gonnaud  P. M., Ochsner  F., Soichot  P., Chan  V., Monnier  G.
ISSN
0148-639X (Print)
Statut éditorial
Publié
Date de publication
07/2000
Peer-reviewed
Oui
Volume
23
Numéro
7
Pages
1089-94
Notes
Clinical Trial Journal Article --- Old month value: Jul
Résumé
We studied the percentage change in compound muscle action potential (CMAP) amplitude and area during and after a 5-min maximal contraction of the muscle. The exercise test (ET) was performed on 64 patients with different muscle disorders and on 46 normal controls. The range of normal ET values was defined as the mean + 2 SD of the control values. The mean sensitivity of the test was 63% in the whole group with ion channel muscle disorders, the highest sensitivity being seen in primary periodic paralysis (81%) and the lowest in chloride channelopathies (17%). In thyrotoxic periodic paralysis, the ET was abnormal in the three of the four patients studied. In patients with myotonic dystrophy, a smaller than normal increase in CMAP amplitude occurred during and after exercise, whereas in proximal myotonic myopathy a normal initial increase in CMAP amplitude was followed by an abnormal decrement. We conclude that the ET can be of use in confirming abnormal muscle membrane excitability in patients with calcium and sodium channelopathies and thyrotoxic periodic paralysis. In chloride channelopathy, the test may also be abnormal, but shows no, or only a small, increase in amplitude or area in the immediate postexercise period. The test may also be abnormal in proximal myotonic myopathy, but is normal in myotonic dystrophy.
Mots-clé
Action Potentials/physiology *Exercise Test Humans Hypokalemic Periodic Paralysis/physiopathology Ion Channels/*physiology Muscular Diseases/*physiopathology Paralysis, Hyperkalemic Periodic/physiopathology Prospective Studies Time Factors
Pubmed
Web of science
Création de la notice
25/01/2008 13:43
Dernière modification de la notice
03/03/2018 18:47
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