Localization of the VHR phosphatase gene and its analysis as a candidate for BRCA1.
Details
Serval ID
serval:BIB_80FBE25C71D5
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Localization of the VHR phosphatase gene and its analysis as a candidate for BRCA1.
Journal
Genomics
ISSN
0888-7543
Publication state
Published
Issued date
1994
Peer-reviewed
Oui
Volume
23
Number
1
Pages
163-167
Language
english
Abstract
The VH1-related human protein (VHR) gene was localized to human chromosome 17q21 in a region thought to contain the BRCA1 locus, a locus that confers susceptibility to breast and ovarian cancer. VHR encodes a phosphatase with dual specificity for tyrosine and serine residues. Thus it is a plausible candidate for a tumor suppressor gene such as BRCA1. To test this possibility, the VHR coding sequence was screened in individuals with familial breast cancer and in sporadic breast tumor and breast cancer cell lines. No mutations were detected, suggesting that the VHR gene is not BRCA1.
Keywords
BRCA1 Protein, Base Sequence, Breast Neoplasms/genetics, Breast Neoplasms/pathology, Chromosomes, Human, Pair 17, DNA Mutational Analysis, DNA, Complementary/genetics, DNA, Neoplasm/genetics, Dual Specificity Phosphatase 3, Female, Genes, Genes, Tumor Suppressor, Genetic Predisposition to Disease, Humans, Molecular Sequence Data, Neoplasm Proteins/genetics, Neoplasm Proteins/physiology, Polymerase Chain Reaction, Polymorphism, Genetic, Polymorphism, Single-Stranded Conformational, Protein Tyrosine Phosphatases/genetics, RNA, Messenger/genetics, RNA, Neoplasm/genetics, Transcription Factors, Tumor Cells, Cultured
Pubmed
Create date
12/03/2008 13:43
Last modification date
20/08/2019 15:41
Usage data
