A global profile of germline gene expression in C. elegans.

Détails

ID Serval
serval:BIB_80A3DFE35E59
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
A global profile of germline gene expression in C. elegans.
Périodique
Molecular Cell
Auteur(s)
Reinke V., Smith H.E., Nance J., Wang J., Van Doren C., Begley R., Jones S.J., Davis E.B., Scherer S., Ward S., Kim S.K.
ISSN
1097-2765
Statut éditorial
Publié
Date de publication
2000
Peer-reviewed
Oui
Volume
6
Numéro
3
Pages
605-616
Langue
anglais
Résumé
We used DNA microarrays to profile gene expression patterns in the C. elegans germline and identified 1416 germline-enriched transcripts that define three groups. The sperm-enriched group contains an unusually large number of protein kinases and phosphatases. The oocyte-enriched group includes potentially new components of embryonic signaling pathways. The germline-intrinsic group, defined as genes expressed similarly in germlines making only sperm or only oocytes, contains a family of piwi-related genes that may be important for stem cell proliferation. Finally, examination of the chromosomal location of germline transcripts revealed that sperm-enriched and germline-intrinsic genes are nearly absent from the X chromosome, but oocyte-enriched genes are not.
Mots-clé
Animals, Caenorhabditis elegans/genetics, Caenorhabditis elegans Proteins, Cell Cycle Proteins/genetics, Cytoskeletal Proteins/genetics, Drosophila Proteins, Gene Expression Profiling, Gene Expression Regulation, Developmental, Helminth Proteins/genetics, Male, Membrane Proteins/genetics, Oocytes/physiology, Proteins/genetics, RNA, Messenger/genetics, RNA-Induced Silencing Complex, Receptors, Notch, Spermatogenesis/genetics, Spermatozoa/physiology, X Chromosome
Pubmed
Web of science
Open Access
Oui
Création de la notice
19/11/2007 10:36
Dernière modification de la notice
20/08/2019 14:41
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