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A global profile of germline gene expression in C. elegans.
We used DNA microarrays to profile gene expression patterns in the C. elegans germline and identified 1416 germline-enriched transcripts that define three groups. The sperm-enriched group contains an unusually large number of protein kinases and phosphatases. The oocyte-enriched group includes potentially new components of embryonic signaling pathways. The germline-intrinsic group, defined as genes expressed similarly in germlines making only sperm or only oocytes, contains a family of piwi-related genes that may be important for stem cell proliferation. Finally, examination of the chromosomal location of germline transcripts revealed that sperm-enriched and germline-intrinsic genes are nearly absent from the X chromosome, but oocyte-enriched genes are not.
Animals, Caenorhabditis elegans/genetics, Caenorhabditis elegans Proteins, Cell Cycle Proteins/genetics, Cytoskeletal Proteins/genetics, Drosophila Proteins, Gene Expression Profiling, Gene Expression Regulation, Developmental, Helminth Proteins/genetics, Male, Membrane Proteins/genetics, Oocytes/physiology, Proteins/genetics, RNA, Messenger/genetics, RNA-Induced Silencing Complex, Receptors, Notch, Spermatogenesis/genetics, Spermatozoa/physiology, X Chromosome
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