A global profile of germline gene expression in C. elegans.
Details
Serval ID
serval:BIB_80A3DFE35E59
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
A global profile of germline gene expression in C. elegans.
Journal
Molecular Cell
ISSN
1097-2765
Publication state
Published
Issued date
2000
Peer-reviewed
Oui
Volume
6
Number
3
Pages
605-616
Language
english
Abstract
We used DNA microarrays to profile gene expression patterns in the C. elegans germline and identified 1416 germline-enriched transcripts that define three groups. The sperm-enriched group contains an unusually large number of protein kinases and phosphatases. The oocyte-enriched group includes potentially new components of embryonic signaling pathways. The germline-intrinsic group, defined as genes expressed similarly in germlines making only sperm or only oocytes, contains a family of piwi-related genes that may be important for stem cell proliferation. Finally, examination of the chromosomal location of germline transcripts revealed that sperm-enriched and germline-intrinsic genes are nearly absent from the X chromosome, but oocyte-enriched genes are not.
Keywords
Animals, Caenorhabditis elegans/genetics, Caenorhabditis elegans Proteins, Cell Cycle Proteins/genetics, Cytoskeletal Proteins/genetics, Drosophila Proteins, Gene Expression Profiling, Gene Expression Regulation, Developmental, Helminth Proteins/genetics, Male, Membrane Proteins/genetics, Oocytes/physiology, Proteins/genetics, RNA, Messenger/genetics, RNA-Induced Silencing Complex, Receptors, Notch, Spermatogenesis/genetics, Spermatozoa/physiology, X Chromosome
Pubmed
Web of science
Open Access
Yes
Create date
19/11/2007 11:36
Last modification date
20/08/2019 15:41