Dendritic cell-based approaches for therapeutic immune regulation in solid-organ transplantation.

Détails

Ressource 1Télécharger: 24307940_BIB_7E481F484BA2.pdf (952.80 [Ko])
Etat: Serval
Version: Final published version
Licence: CC BY 4.0
ID Serval
serval:BIB_7E481F484BA2
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
Dendritic cell-based approaches for therapeutic immune regulation in solid-organ transplantation.
Périodique
Journal of Transplantation
Auteur(s)
Vassalli G.
ISSN
2090-0007 (Print)
ISSN-L
2090-0007
Statut éditorial
Publié
Date de publication
2013
Peer-reviewed
Oui
Volume
2013
Pages
761429
Langue
anglais
Notes
Publication types: Journal Article ; Review - pdf : review
Résumé
To avoid immune rejection, allograft recipients require drug-based immunosuppression, which has significant toxicity. An emerging approach is adoptive transfer of immunoregulatory cells. While mature dendritic cells (DCs) present donor antigen to the immune system, triggering rejection, regulatory DCs interact with regulatory T cells to promote immune tolerance. Intravenous injection of immature DCs of either donor or host origin at the time of transplantation have prolonged allograft survival in solid-organ transplant models. DCs can be treated with pharmacological agents before injection, which may attenuate their maturation in vivo. Recent data suggest that injected immunosuppressive DCs may inhibit allograft rejection, not by themselves, but through conventional DCs of the host. Genetically engineered DCs have also been tested. Two clinical trials in type-1 diabetes and rheumatoid arthritis have been carried out, and other trials, including one trial in kidney transplantation, are in progress or are imminent.
Pubmed
Open Access
Oui
Création de la notice
18/01/2015 18:04
Dernière modification de la notice
28/05/2019 15:01
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