Acute lobular hepatitis as the first manifestation of recurrent autoimmune hepatitis after orthotopic liver transplantation.

Details

Serval ID
serval:BIB_7D298029EDCD
Type
Article: article from journal or magazin.
Publication sub-type
Case report (case report): feedback on an observation with a short commentary.
Collection
Publications
Title
Acute lobular hepatitis as the first manifestation of recurrent autoimmune hepatitis after orthotopic liver transplantation.
Journal
Liver
Author(s)
Sempoux C., Horsmans Y., Lerut J., Rahier J., Geubel A.
ISSN
0106-9543 (Print)
ISSN-L
0106-9543
Publication state
Published
Issued date
1997
Peer-reviewed
Oui
Volume
17
Number
6
Pages
311-315
Language
english
Notes
Publication types: Case Reports ; Journal ArticlePublication Status: ppublish
Abstract
Recurrence of autoimmune hepatitis after orthotopic liver transplantation and after reduction in immunosuppressive treatment is reported in a 43-year-old man. Diagnosis was based on biological, serological and morphological data, as well as on a complete biological recovery following steroid resumption. Recurrence was observed only 4 months after transplantation, when an abrupt increase in liver function tests was observed in association with a mainly lobular hepatitis in liver biopsy. Such a histological appearance has been previously described in the case of recurrence after immunosuppressive treatment weaning in non-transplanted patients. In contrast, this histological feature has not been reported in the rare transplanted patients in whom such recurrence has been observed. Thereafter, the evolution of the disease in our patient remained slow, likely dampened by the administration of cyclosporine and azathioprine. Morphological features are detailed, and importance of immunosuppressive therapy in patients transplanted for end-stage autoimmune hepatitis is emphasized.
Keywords
Acute Disease, Adult, Biopsy, Follow-Up Studies, Glucocorticoids/therapeutic use, Hepatitis/drug therapy, Hepatitis/etiology, Hepatitis, Autoimmune/drug therapy, Hepatitis, Autoimmune/etiology, Humans, Immunosuppressive Agents/therapeutic use, Liver Failure/pathology, Liver Failure/surgery, Liver Transplantation/adverse effects, Liver Transplantation/pathology, Male, Recurrence
Pubmed
Web of science
Create date
20/10/2016 16:39
Last modification date
20/08/2019 14:38
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