Precursors of functional MHC class I- or class II-restricted CD8alphaalpha(+) T cells are positively selected in the thymus by agonist self-peptides.

Details

Serval ID
serval:BIB_7C976D1ADD13
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Precursors of functional MHC class I- or class II-restricted CD8alphaalpha(+) T cells are positively selected in the thymus by agonist self-peptides.
Journal
Immunity
Author(s)
Leishman A.J., Gapin L., Capone M., Palmer E., MacDonald H.R., Kronenberg M., Cheroutre H.
ISSN
1074-7613
Publication state
Published
Issued date
2002
Peer-reviewed
Oui
Volume
16
Number
3
Pages
355-364
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, P.H.S.
Publication Status: ppublish
Abstract
The origin and specificity of alphabeta TCR(+) T cells that express CD8alphaalpha have been controversial issues. Here we provide direct evidence that precursors of functional CD8alphaalpha T cells are positively selected in the thymus in the presence of agonist self-peptides. Like conventional positive selection, this agonist selection process requires functional TCR alpha-CPM, whereas it is independent of CD8beta expression. Furthermore, CD8alphaalpha expression on mature, agonist-selected T cells does not imply selection by MHC class I, and CD8alphaalpha(+) T cells can be either class I or class II restricted. Our data define a distinct agonist-dependent, positive selection process in the thymus, and they suggest a function for CD8alphaalpha distinct from the conventional TCR coreceptor function of CD8alphabeta or CD4.
Keywords
Animals, Antigen Presentation, Antigens, CD8/immunology, CD8-Positive T-Lymphocytes/immunology, Histocompatibility Antigens Class I/immunology, Histocompatibility Antigens Class II/immunology, Mice, Mice, Transgenic, Thymus Gland/immunology
Pubmed
Web of science
Open Access
Yes
Create date
11/02/2010 9:54
Last modification date
20/08/2019 14:38
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