Replicated analysis of the genetic architecture of quantitative traits in two wild great tit populations.

Détails

ID Serval
serval:BIB_7C4FEA616F0C
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Replicated analysis of the genetic architecture of quantitative traits in two wild great tit populations.
Périodique
Molecular Ecology
Auteur(s)
Santure A.W., Poissant J., De Cauwer I., van Oers K., Robinson M.R., Quinn J.L., Groenen M.A., Visser M.E., Sheldon B.C., Slate J.
ISSN
1365-294X (Electronic)
ISSN-L
0962-1083
Statut éditorial
Publié
Date de publication
2015
Peer-reviewed
Oui
Volume
24
Numéro
24
Pages
6148-6162
Langue
anglais
Résumé
Currently, there is much debate on the genetic architecture of quantitative traits in wild populations. Is trait variation influenced by many genes of small effect or by a few genes of major effect? Where is additive genetic variation located in the genome? Do the same loci cause similar phenotypic variation in different populations? Great tits (Parus major) have been studied extensively in long-term studies across Europe and consequently are considered an ecological 'model organism'. Recently, genomic resources have been developed for the great tit, including a custom SNP chip and genetic linkage map. In this study, we used a suite of approaches to investigate the genetic architecture of eight quantitative traits in two long-term study populations of great tits--one in the Netherlands and the other in the United Kingdom. Overall, we found little evidence for the presence of genes of large effects in either population. Instead, traits appeared to be influenced by many genes of small effect, with conservative estimates of the number of contributing loci ranging from 31 to 310. Despite concordance between population-specific heritabilities, we found no evidence for the presence of loci having similar effects in both populations. While population-specific genetic architectures are possible, an undetected shared architecture cannot be rejected because of limited power to map loci of small and moderate effects. This study is one of few examples of genetic architecture analysis in replicated wild populations and highlights some of the challenges and limitations researchers will face when attempting similar molecular quantitative genetic studies in free-living populations.

Mots-clé
Animals, Chromosome Mapping, Genetic Association Studies, Genetics, Population, Genotype, Netherlands, Passeriformes/genetics, Phenotype, Polymorphism, Single Nucleotide, Quantitative Trait Loci, United Kingdom, GWAS, QTL mapping, chromosome partitioning, genome-wide association, genomics, quantitative genetics
Pubmed
Web of science
Open Access
Oui
Création de la notice
06/12/2017 13:42
Dernière modification de la notice
08/05/2019 20:53
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