N-methyl-D-aspartate receptor encephalitis: laboratory diagnostics and comparative clinical features in adults and children.

Détails

ID Serval
serval:BIB_7A1F16FE8EC1
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
N-methyl-D-aspartate receptor encephalitis: laboratory diagnostics and comparative clinical features in adults and children.
Périodique
Expert review of molecular diagnostics
Auteur(s)
Gastaldi M., Nosadini M., Spatola M., Sartori S., Franciotta D.
ISSN
1744-8352 (Electronic)
ISSN-L
1473-7159
Statut éditorial
Publié
Date de publication
02/2018
Peer-reviewed
Oui
Volume
18
Numéro
2
Pages
181-193
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't ; Review
Publication Status: ppublish
Résumé
N-methyl-D-aspartate receptor (NMDAR) encephalitis is the most common autoimmune encephalitis due to autoantibodies against neuronal surface antigens, can affect both children and adults, leading to neurological and neuropsychological sequelae. However, it is potentially treatable and the prompt start of immunotherapy associates with better prognosis. Conversely, misdiagnosis can be harmful. The detection of NMDAR antibodies in serum and cerebrospinal fluid plays a pivotal role in the diagnostic work-up. Reliable methods for NMDAR antibody detection are thus fundamental to assure accurate diagnosis and allow early treatments. Areas covered: This review recapitulates the pathogenic mechanisms of NMDAR encephalitis as a model of antibody mediated synaptopathy, and gives insights into the related state-of-the-art laboratory testing. The differences in clinical presentations, tumor associations and responses to treatments between adults and children are also described. Expert commentary: The relevance of NMDAR encephalitis has placed neuroimmunology laboratories in a crucial position, but methods for NMDAR antibody detection are awaiting thorough and consensus-based standardizations. In the next few years, this process, along with novel insights into the pathogenic mechanisms, could improve the disease management and clarify the still pending role of NMDAR antibodies in healthy people and in other more common neuropsychiatric disorders.
Mots-clé
Age Factors, Animals, Autoantibodies/blood, Autoantibodies/immunology, Autoimmunity, Diagnosis, Differential, Encephalitis/diagnosis, Encephalitis/etiology, Encephalitis/immunology, Encephalitis/metabolism, Encephalitis/therapy, Hashimoto Disease/diagnosis, Hashimoto Disease/immunology, Humans, Neoplasms/complications, Prognosis, Receptors, N-Methyl-D-Aspartate/immunology, Receptors, N-Methyl-D-Aspartate/metabolism, Recurrence, Schizophrenia/complications, Symptom Assessment, Virus Diseases/complications, Autoimmune encephalitis, cell-based assay, immunohistochemistry, immunosuppressive therapies, neuroimmunology, neuropsychiatric disorders, paraneoplastic neurological syndrome
Pubmed
Web of science
Création de la notice
01/02/2018 19:41
Dernière modification de la notice
11/02/2019 7:11
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