A prospective study of skeletal changes during short-term acitretin therapy

Détails

ID Serval
serval:BIB_79EE4DA6D893
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
A prospective study of skeletal changes during short-term acitretin therapy
Périodique
Dermatology
Auteur(s)
Hohl  D., Pelloni  F., Sigg  C., Gilardi  S., Jung  T.
ISSN
1018-8665 (Print)
Statut éditorial
Publié
Date de publication
1992
Volume
185
Numéro
1
Pages
23-6
Notes
Journal Article
Résumé
We prospectively analyzed skeletal changes of 16 patients who were treated with acitretin for various disorders of keratinization at doses of 10-50 mg/day (overall mean 0.4 mg/kg/day) for 7-12 months (mean 11.4 months). Skeletal changes from pretherapy findings were observed in 5 patients. In 4 of 5 patients they appeared to be linked to a preexisting degenerative pathology and could not be attributed to acitretin therapy. However, in 1 patient a spinal osseous side effect could not be excluded. No retinoid-induced extraspinal tendon or ligament calcifications were observed.
Mots-clé
Acitretin Adolescent Bone Diseases/*chemically induced Bone and Bones/drug effects Female Humans Male Middle Aged Prospective Studies Skin Diseases/*drug therapy Spinal Diseases/chemically induced Tretinoin/adverse effects/*analogs & derivatives
Pubmed
Web of science
Création de la notice
25/01/2008 17:36
Dernière modification de la notice
03/03/2018 18:32
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