Article: article from journal or magazin.
A prospective study of skeletal changes during short-term acitretin therapy
We prospectively analyzed skeletal changes of 16 patients who were treated with acitretin for various disorders of keratinization at doses of 10-50 mg/day (overall mean 0.4 mg/kg/day) for 7-12 months (mean 11.4 months). Skeletal changes from pretherapy findings were observed in 5 patients. In 4 of 5 patients they appeared to be linked to a preexisting degenerative pathology and could not be attributed to acitretin therapy. However, in 1 patient a spinal osseous side effect could not be excluded. No retinoid-induced extraspinal tendon or ligament calcifications were observed.
Acitretin Adolescent Bone Diseases/*chemically induced Bone and Bones/drug effects Female Humans Male Middle Aged Prospective Studies Skin Diseases/*drug therapy Spinal Diseases/chemically induced Tretinoin/adverse effects/*analogs & derivatives
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