Diagnostic performance of dedicated positron emission mammography using fluorine-18-fluorodeoxyglucose in women with suspicious breast lesions: a meta-analysis.

Details

Serval ID
serval:BIB_7951FEA570DC
Type
Article: article from journal or magazin.
Collection
Publications
Title
Diagnostic performance of dedicated positron emission mammography using fluorine-18-fluorodeoxyglucose in women with suspicious breast lesions: a meta-analysis.
Journal
Clinical breast cancer
Author(s)
Caldarella C., Treglia G., Giordano A.
ISSN
1938-0666 (Electronic)
ISSN-L
1526-8209
Publication state
Published
Issued date
08/2014
Peer-reviewed
Oui
Volume
14
Number
4
Pages
241-248
Language
english
Notes
Publication types: Journal Article ; Meta-Analysis
Publication Status: ppublish
Abstract
The diagnostic performance of dedicated positron emission mammography (PEM) using fluorine-18-fluorodeoxyglucose (FDG) in evaluating suspicious breast lesions has been investigated by several authors, with conflicting results. Aim of our study is to meta-analyze published data about this topic, in order to add evidence-based data in this setting.
We carried out a comprehensive computer literature search of studies published in the PubMed/MEDLINE, Scopus, or Embase databases through February 10, 2013, regarding the diagnostic performance of PEM using FDG in women with breast lesions. Only studies comprising ≥ 10 patients who underwent PEM were included in the meta-analysis, for statistical purposes. Pooled sensitivity and specificity on a per lesion-based analysis were calculated to assess the diagnostic performance of PEM using FDG in this setting.
Our meta-analysis evaluated 8 studies comprising 873 women with breast lesions. Pooled sensitivity and specificity values of PEM using FDG in women with suspected breast malignancy were 85% (95% CI, 83%-88%) and 79% (95% CI, 74%-83%), respectively, on a per lesion-based analysis. The included studies were heterogeneous in their estimate of sensitivity and specificity.
PEM using FDG is a sensitive and specific tool for the evaluation of suspicious breast lesions. The detection of additional lesions and extensive intraductal involvement is improved, with comparable accuracy, over that of MRI in the depiction of invasive breast cancers.

Keywords
Breast Neoplasms/diagnosis, Breast Neoplasms/prevention & control, Female, Fluorodeoxyglucose F18, Humans, Positron-Emission Tomography/methods, Prognosis, Radiopharmaceuticals, Sensitivity and Specificity, Accuracy of diagnostic studies, Breast malignancy, PEM, Sensitivity and specificity, Statistical pooled evaluation
Pubmed
Web of science
Create date
20/08/2017 18:43
Last modification date
20/08/2019 14:35
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