Case study of intracerebral plasmacytoma as an initial presentation of multiple myeloma.

Details

Serval ID
serval:BIB_78BEEE06B310
Type
Article: article from journal or magazin.
Publication sub-type
Case report (case report): feedback on an observation with a short commentary.
Collection
Publications
Institution
Title
Case study of intracerebral plasmacytoma as an initial presentation of multiple myeloma.
Journal
Neuro-oncology
Author(s)
Wavre A., Baur A.S., Betz M., Mühlematter D., Jotterand M., Zaman K., Ketterer N.
ISSN
1522-8517
Publication state
Published
Issued date
2007
Peer-reviewed
Oui
Volume
9
Number
3
Pages
370-2
Language
english
Notes
Publication types: Case Reports ; Journal Article - Publication Status: ppublish
Abstract
Cerebral involvement is an uncommon complication of multiple myeloma. We report on a 64-year-old man hospitalized for a partial seizure. MRI showed two intracerebral lesions, which proved to be plasmacytomas. After complete staging, we retained the diagnosis of immunoglobulin G lambda-type multiple myeloma with CNS involvement. Cytogenetic analysis of plasma cells detected a deletion in the p53 gene at 17p13.1. Despite cranial radiotherapy and systemic chemotherapy, the patient's disease progressed rapidly and he died five months after diagnosis. What makes this case unusual is that overt multiple myeloma had been absent before cerebral involvement was discovered. It confirms the extremely poor prognosis of patients with CNS myeloma even in the presence of aggressive treatment. Cytogenetic abnormalities could be a marker of chromosomal and genetic instability, conferring to multiple myeloma a more aggressive profile.
Keywords
Brain Neoplasms, Diabetes Mellitus, Type 2, Fatal Outcome, Gene Deletion, Genes, p53, Humans, Immunohistochemistry, In Situ Hybridization, Magnetic Resonance Imaging, Male, Middle Aged, Multiple Myeloma, Plasmacytoma
Pubmed
Web of science
Open Access
Yes
Create date
30/07/2008 10:14
Last modification date
20/08/2019 14:35
Usage data