Article: article from journal or magazin.
Case report (case report): feedback on an observation with a short commentary.
Case study of intracerebral plasmacytoma as an initial presentation of multiple myeloma.
Publication types: Case Reports ; Journal Article - Publication Status: ppublish
Cerebral involvement is an uncommon complication of multiple myeloma. We report on a 64-year-old man hospitalized for a partial seizure. MRI showed two intracerebral lesions, which proved to be plasmacytomas. After complete staging, we retained the diagnosis of immunoglobulin G lambda-type multiple myeloma with CNS involvement. Cytogenetic analysis of plasma cells detected a deletion in the p53 gene at 17p13.1. Despite cranial radiotherapy and systemic chemotherapy, the patient's disease progressed rapidly and he died five months after diagnosis. What makes this case unusual is that overt multiple myeloma had been absent before cerebral involvement was discovered. It confirms the extremely poor prognosis of patients with CNS myeloma even in the presence of aggressive treatment. Cytogenetic abnormalities could be a marker of chromosomal and genetic instability, conferring to multiple myeloma a more aggressive profile.
Brain Neoplasms, Diabetes Mellitus, Type 2, Fatal Outcome, Gene Deletion, Genes, p53, Humans, Immunohistochemistry, In Situ Hybridization, Magnetic Resonance Imaging, Male, Middle Aged, Multiple Myeloma, Plasmacytoma
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