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BAFF-R, a newly identified TNF receptor that specifically interacts with BAFF.
B cell homeostasis has been shown to critically depend on BAFF, the B cell activation factor from the tumor necrosis factor (TNF) family. Although BAFF is already known to bind two receptors, BCMA and TACI, we have identified a third receptor for BAFF that we have termed BAFF-R. BAFF-R binding appears to be highly specific for BAFF, suggesting a unique role for this ligand-receptor interaction. Consistent with this, the BAFF-R locus is disrupted in A/WySnJ mice, which display a B cell phenotype qualitatively similar to that of the BAFF-deficient mice. Thus, BAFF-R appears to be the principal receptor for BAFF-mediated mature B cell survival.
Amino Acid Sequence, Animals, B-Cell Activating Factor, B-Cell Activation Factor Receptor, B-Cell Maturation Antigen, B-Lymphocytes/immunology, B-Lymphocytes/metabolism, Cell Line, Chromosome Mapping, Chromosomes, Human, Pair 22, Cloning, Molecular, Homeostasis, Humans, Ligands, Lymphoid Tissue/metabolism, Male, Membrane Proteins/metabolism, Mice, Mice, Inbred A, Mice, Inbred C57BL, Molecular Sequence Data, RNA, Messenger/chemistry, RNA, Messenger/genetics, Receptors, Tumor Necrosis Factor/chemistry, Receptors, Tumor Necrosis Factor/genetics, Recombinant Fusion Proteins/metabolism, Signal Transduction, Transfection, Transmembrane Activator and CAML Interactor Protein, Tumor Necrosis Factor-alpha/metabolism
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