Endogenous synthesis of peptidoglycan in eukaryotic cells; a novel concept involving its essential role in cell division, tumor formation and the biological clock

Détails

ID Serval
serval:BIB_732F8ECF5069
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Endogenous synthesis of peptidoglycan in eukaryotic cells; a novel concept involving its essential role in cell division, tumor formation and the biological clock
Périodique
Experientia
Auteur(s)
Roten  C. A., Karamata  D.
ISSN
0014-4754 (Print)
Statut éditorial
Publié
Date de publication
10/1992
Volume
48
Numéro
10
Pages
921-31
Notes
Journal Article
Review --- Old month value: Oct 15
Résumé
Degradation products of peptidoglycan, the universal bacterial cell wall constituent, were previously found in animal tissues and urine. Reassessment and quantitative analysis of available data lead to an original concept, i.e. that eukaryotic cells synthesize peptidoglycan. We present a model in which this endogenously synthesized peptidoglycan is essential for the processes of eukaryotic cell division and sleep induction in animals. Genes for peptidoglycan metabolism, like those for lysine biosynthesis in plants, are probably inherited from endosymbiotic bacteria, the ancestors of mitochondria and chloroplasts. Corollaries of this concept, i.e. roles for peptidoglycan metabolism in tumor formation and in the biological clock, are supported by abundant evidence. We propose that many interactions between bacteria and eukaryotes are conditioned by their common genetic heritage.
Mots-clé
Animals Bacteria/metabolism Carbohydrate Sequence Humans Molecular Sequence Data Peptidoglycan/*biosynthesis/chemistry/metabolism Periodicity Phylogeny Plants/metabolism
Pubmed
Web of science
Création de la notice
24/01/2008 15:07
Dernière modification de la notice
03/03/2018 18:18
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