Abnormal cortical network activation in human amnesia: A high-resolution evoked potential study.

Details

Serval ID
serval:BIB_71E9D63251BF
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Abnormal cortical network activation in human amnesia: A high-resolution evoked potential study.
Journal
Brain Topography
Author(s)
Barcellona-Lehmann Sandra, Morand Stephanie, Bindschaedler Claire, Nahum Louis, Gabriel Damien, Schnider Armin
ISSN
1573-6792[electronic], 0896-0267[linking]
Publication state
Published
Issued date
2010
Volume
23
Number
1
Pages
72-81
Language
english
Abstract
Little is known about how human amnesia affects the activation of cortical networks during memory processing. In this study, we recorded high-density evoked potentials in 12 healthy control subjects and 11 amnesic patients with various types of brain damage affecting the medial temporal lobes, diencephalic structures, or both. Subjects performed a continuous recognition task composed of meaningful designs. Using whole-scalp spatiotemporal mapping techniques, we found that, during the first 200 ms following picture presentation, map configuration of amnesics and controls were indistinguishable. Beyond this period, processing significantly differed. Between 200 and 350 ms, amnesic patients expressed different topographical maps than controls in response to new and repeated pictures. From 350 to 550 ms, healthy subjects showed modulation of the same maps in response to new and repeated items. In amnesics, by contrast, presentation of repeated items induced different maps, indicating distinct cortical processing of new and old information. The study indicates that cortical mechanisms underlying memory formation and re-activation in amnesia fundamentally differ from normal memory processing.
Keywords
Amnesia, Recognition Memory, Encoding, Brain Damage, Evoked Potentials, Brain Mapping, EEG, Spatiotemporal Analysis, Wernicke-Korsakoff-Syndrome, Recognition Memory, Hippocampal Damage, Ongoing Reality, Retrieval, Pet, Recollection, Dissociation, Familiarity, Repetition
Pubmed
Web of science
Create date
24/02/2010 13:29
Last modification date
20/08/2019 14:30
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