Making sense of AMPA receptor trafficking by modeling molecular mechanisms of synaptic plasticity.

Details

Serval ID
serval:BIB_6F7E69A6B96F
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Making sense of AMPA receptor trafficking by modeling molecular mechanisms of synaptic plasticity.
Journal
Brain research
Author(s)
Langemann D., Pellerin L., Peters A.
ISSN
0006-8993
Publication state
Published
Issued date
2008
Peer-reviewed
Oui
Volume
1207
Pages
60-72
Language
english
Abstract
Synaptic plasticity involves a complex molecular machinery with various protein interactions but it is not yet clear how its components give rise to the different aspects of synaptic plasticity. Here we ask whether it is possible to mathematically model synaptic plasticity by making use of known substances only. We present a model of a multistable biochemical reaction system and use it to simulate the plasticity of synaptic transmission in long-term potentiation (LTP) or long-term depression (LTD) after repeated excitation of the synapse. According to our model, we can distinguish between two phases: first, a "viscosity" phase after the first excitation, the effects of which like the activation of NMDA receptors and CaMKII fade out in the absence of further excitations. Second, a "plasticity" phase actuated by an identical subsequent excitation that follows after a short time interval and causes the temporarily altered concentrations of AMPA subunits in the postsynaptic membrane to be stabilized. We show that positive feedback is the crucial element in the core chemical reaction, i.e. the activation of the short-tail AMPA subunit by NEM-sensitive factor, which allows generating multiple stable equilibria. Three stable equilibria are related to LTP, LTD and a third unfixed state called ACTIVE. Our mathematical approach shows that modeling synaptic multistability is possible by making use of known substances like NMDA and AMPA receptors, NEM-sensitive factor, glutamate, CaMKII and brain-derived neurotrophic factor. Furthermore, we could show that the heteromeric combination of short- and long-tail AMPA receptor subunits fulfills the function of a memory tag.
Keywords
Animals, Feedback, Mathematics, Mice, Models, Biological, Neuronal Plasticity, Protein Transport, Receptors, AMPA, Synaptic Transmission
Pubmed
Web of science
Create date
31/03/2009 16:29
Last modification date
20/08/2019 14:28
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