A computer model of cardiac electrical activity for the simulation of arrhythmias

Details

Serval ID
serval:BIB_6EED3E186B11
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
A computer model of cardiac electrical activity for the simulation of arrhythmias
Journal
Pacing and Clinical Electrophysiology
Author(s)
Virag  N., Vesin  J. M., Kappenberger  L.
ISSN
0147-8389 (Print)
Publication state
Published
Issued date
11/1998
Volume
21
Number
11 Pt 2
Pages
2366-71
Notes
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Nov
Abstract
Modern computer power allows development of models of the heart that may be helpful for the understanding of arrhythmia mechanisms if, based on realistic physiological parameters, such models can display phenomena difficult to study in nature. Therefore, a two-dimensional model of the cardiac tissue has been implemented, where the modeling of each cell is based on membrane ionic channels (Beeler-Reuter and Luo-Rudy models). In addition, an ECG was computed based on the ionic currents simulated. This model allows us to observe the propagation of the action potentials Vm across the cardiac tissue, the evolution of Vm for any of the cardiac cells, and the underlying ionic currents. The computation of the ECG makes it possible to relate this information with an often-used diagnostic tool. Simulations of normal and pathological phenomena such as functional and anatomic reentry have been performed. Our simulation results show that the applied computer model based on ionic currents seems accurate and realistic when compared with biological models and offers a new approach to study the origin, prevention, and termination of arrhythmias.
Keywords
Action Potentials/physiology Arrhythmia/*physiopathology *Computer Simulation *Electrocardiography Heart Conduction System/*physiopathology Humans *Models, Cardiovascular
Pubmed
Web of science
Create date
15/02/2008 12:29
Last modification date
20/08/2019 15:28
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