Pneumopathie organisée cryptogénique [Cryptogenic organizing pneumonia]

Détails

ID Serval
serval:BIB_6D996158B743
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
Pneumopathie organisée cryptogénique [Cryptogenic organizing pneumonia]
Périodique
Revue des maladies respiratoires
Auteur(s)
Petitpierre N., Beigelman C., Letovanec I., Lazor R.
ISSN
1776-2588 (Electronic)
ISSN-L
0761-8425
Statut éditorial
Publié
Date de publication
10/2016
Peer-reviewed
Oui
Volume
33
Numéro
8
Pages
703-717
Langue
français
Notes
Publication types: Journal Article ; Review
Publication Status: ppublish
Résumé
Organizing pneumonia is a particular type of inflammatory reaction of the lung which gives rise to a clinico-pathological syndrome. It is called "secondary" when a cause such as an infection, a drug toxicity, or a connective tissue disease can be identified, or "cryptogenic" when no cause is identified. The clinical picture is usually characterized by the subacute onset of fever, fatigue, cough and dyspnea, with multiple subpleural areas of consolidation on thoracic imaging.
Organizing pneumonia is characterised by the presence of buds of endoalveolar connective tissue. These result from an injury to the alveolar epithelium, followed by the deposition of fibrin in the alveolar spaces, and the migration of fibroblasts which produce a myxoid endoalveolar matrix. A remarkable feature of organizing pneumonia is the complete disappearance of these endoalveolar buds with corticosteroid treatment, in sharp contrast with what is seen in pulmonary fibrosis. The clinical response to corticosteroids is usually prompt and excellent. Relapses are frequent but usually benign.
As the clinical, imaging and pathological characteristics of organizing pneumonia are now well established, many questions remain unanswered, such as the mechanisms involved in the complete reversibility of the pulmonary lesions, and the role of steroid-sparing treatments such as immunomodulatory macrolides.

Mots-clé
Cryptogenic Organizing Pneumonia/classification, Cryptogenic Organizing Pneumonia/diagnosis, Cryptogenic Organizing Pneumonia/pathology, Cryptogenic Organizing Pneumonia/therapy, Diagnosis, Differential, Glucocorticoids/therapeutic use, Humans, Recurrence, Terminology as Topic, Bronchiolite oblitérante avec organisation pneumonique, Bronchiolitis obliterans organizing pneumonia, Cryptogenic organizing pneumonia, Glucocorticoids, Glucocorticoïdes, Idiopathic interstitial pneumonia, Pneumopathie interstitielle idiopathique, Pneumopathie organisée cryptogénique, Rechutes, Relapses
Pubmed
Web of science
Création de la notice
02/12/2016 13:37
Dernière modification de la notice
20/08/2019 15:27
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