Roles of cellular respiration, CgCDR1, and CgCDR2 in Candida glabrata resistance to histatin 5

Helmerhorst,  E. J.; Venuleo,  C.; Sanglard,  D.; Oppenheim,  F. G.

doi:10.1128/AAC.50.3.1100-1103.2006

Roles of cellular respiration, CgCDR1, and CgCDR2 in Candida glabrata resistance to histatin 5

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Serval ID

serval:BIB_6AEE4FDFCBEB

Type

Article: article from journal or magazin.

Collection

Publications

Institution

UNIL/CHUV

Title

Roles of cellular respiration, CgCDR1, and CgCDR2 in Candida glabrata resistance to histatin 5

Journal

Antimicrobial Agents and Chemotherapy

Author(s)

Helmerhorst E. J., Venuleo C., Sanglard D., Oppenheim F. G.

ISSN

0066-4804 (Print)

Publication state

Published

Issued date

03/2006

Volume

Number

Pages

1100-3

Notes

Journal Article
Research Support, N.I.H., Extramural --- Old month value: Mar

Abstract

Histatin 5, a human salivary protein with broad-spectrum antifungal activity, is remarkably ineffective against Candida glabrata. Fluconazole resistance in this fungus is due in most cases to upregulation of CgCDR efflux pumps. We investigated whether the distinct resistance of C. glabrata to histatin 5 is related to similar mechanisms.

Keywords

Antifungal Agents/*pharmacology Candida glabrata/*drug effects/genetics/growth & development Culture Media Drug Resistance, Fungal/drug effects/*genetics Gene Expression Regulation, Fungal/drug effects *Genes, Fungal Humans Salivary Proteins/*pharmacology

OAI-PMH

oai:serval.unil.ch:BIB_6AEE4FDFCBEB

DOI

10.1128/AAC.50.3.1100-1103.2006

Pubmed

16495279

Web of science

000235786300041

Open Access

Yes

Create date

25/01/2008 15:40