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Toxicités orales subaigue et sub chronique du beta-bis carboxyethyl sesquioxyde de germanium, chez le rat [Subacute and subchronic oral toxicity of beta-bis carboxyethyl sesquioxide of germanium in the rat]
Journal de Toxicologie Clinique et Expérimentale
After a brief recall of toxicological data about germanium compounds, the authors relate subacute and subchronic oral toxicities of beta bis carboxyethyl-germanium sesquioxide in rats. During 28 days and six months, male and female animals have received 1 mg/kg/day. No particular toxic symptoms, no behaviour trouble except a small decrease of body weight, in male rats, at the end of the 6-month experimentation, were observed. A light decrease of erythropoiesis and a general stimulation of cellular metabolism has been noticed after 28 days. The only marked effect was a moderate renal deficiency characterized by a tubular disease with presence of cylinders, swelling of tubulus cells and floculus amounts after 6 months. Germanium urinary excretion was constant and linked to the received dose. Six months later, no preferential accumulation in organs was observed
Administration,Oral/Animals/Female/Male/Organometallic Compounds/administration & dosage/toxicity/Rabbits/Rats/Rats,Wistar/Time Factors
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