Effects of immunosuppressive drugs on HIV infection: implications for solid-organ transplantation.

Détails

ID Serval
serval:BIB_692DE1D192A8
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
Effects of immunosuppressive drugs on HIV infection: implications for solid-organ transplantation.
Périodique
Transplant International
Auteur(s)
Ciuffreda D., Pantaleo G., Pascual M.
ISSN
0934-0874
Statut éditorial
Publié
Date de publication
2007
Peer-reviewed
Oui
Volume
20
Numéro
8
Pages
649-658
Langue
anglais
Notes
Publication types: Journal Article ; Review - Publication Status: ppublish
Résumé
With the advent of highly active antiretroviral therapy (HAART), HIV infection has become a chronic disease. Various end-stage organ failures have now become common co-morbidities and are primary causes of mortality in HIV-infected patients. Solid-organ transplantation therefore has been proposed to these patients, as HIV infection is not anymore considered an absolute contraindication. The initial results of organ transplantation in HIV-infected patients are encouraging with no differences in patient and graft survival compared with non-HIV-infected patients. The use of immunosuppressive drug therapy in HIV-infected patients has so far not shown major detrimental effects, and some drugs in combination with HAART have even demonstrated possible beneficial effects for specific HIV settings. Nevertheless, organ transplantation in HIV-infected patients remains a complex intervention, and more studies will be required to clarify open questions such as long-term effects of drug interactions between antiretroviral and immunosuppressive drugs, outcome of recurrent HCV infection in HIV-infected patients, incidence of graft rejection, or long-term graft and patient survival. In this article, we first review the immunological pathogenesis of HIV infection and the rationale for using immunosuppression combined with HAART. We then discuss the most recent results of solid-organ transplantation in HIV-infected patients.
Mots-clé
Antiretroviral Therapy, Highly Active, Graft Rejection, HIV, HIV Infections, Humans, Immunosuppressive Agents, Organ Transplantation, Prognosis, Risk Factors, Survival Rate, Virus Replication, World Health
Pubmed
Web of science
Création de la notice
29/01/2008 13:52
Dernière modification de la notice
20/08/2019 14:24
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