Genetic testing in patients with obesity.

Details

Serval ID
serval:BIB_68A46A83BA72
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Genetic testing in patients with obesity.
Journal
Best Practice and Research. Clinical Endocrinology and Metabolism
Author(s)
Phan-Hug F., Beckmann J.S., Jacquemont S.
ISSN
1532-1908 (Electronic)
ISSN-L
1521-690X
Publication state
Published
Issued date
2012
Volume
26
Number
2
Pages
133-143
Language
english
Notes
Publication types: Journal ArticlePublication Status: ppublish
Abstract
The obesity epidemic is associated with the recent availability of highly palatable and inexpensive caloric food as well as important changes in lifestyle. Genetic factors, however, play a key role in regulating energy balance and numerous twin studies have estimated the BMI heritability between 40 and 70%. While common variants, identified through genome-wide association studies (GWAS) point toward new pathways, their effect size are too low to be of any use in the clinic. This review therefore concentrates on genes and genomic regions associated with very high risks of human obesity. Although there are no consensus guidelines, we review how the knowledge on these "causal factors" can be translated into the clinic for diagnostic purposes. We propose genetic workups guided by clinical manifestations in patients with severe early-onset obesity. While etiological diagnoses are unequivocal in a minority of patients, new genomic tools such as Comparative Genomic Hybridization (CGH) array, have allowed the identification of novel "causal" loci and next-generation sequencing brings the promise of accelerated pace for discoveries relevant to clinical practice.
Pubmed
Web of science
Create date
19/05/2012 18:52
Last modification date
20/08/2019 14:23
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