Norepinephrine decreases EGF binding in primary rat hepatocyte cultures.

Détails

ID Serval
serval:BIB_6888D6D114F4
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Norepinephrine decreases EGF binding in primary rat hepatocyte cultures.
Périodique
Journal of Cellular Physiology
Auteur(s)
Cruise J.L., Cotecchia S., Michalopoulos G.
ISSN
0021-9541 (Print)
ISSN-L
0021-9541
Statut éditorial
Publié
Date de publication
1986
Volume
127
Numéro
1
Pages
39-44
Langue
anglais
Résumé
Norepinephrine (NE) produced a dose-dependent inhibition of 125I-epidermal growth factor (EGF) binding to adult rat hepatocytes in primary culture. This effect was maximal after 1 hr of incubation with NE and could be blocked by the presence of an alpha 1-specific adrenergic receptor antagonist. The inhibition of binding correlates with the ability of NE to enhance hepatocyte DNA synthesis in the presence of EGF and appears to be mediated by a reduction in EGF receptor number, without a significant change in receptor affinity.
Mots-clé
Animals, Cells, Cultured, DNA/biosynthesis, Epidermal Growth Factor/metabolism, Female, Liver/cytology, Liver/drug effects, Norepinephrine/pharmacology, Pindolol/pharmacology, Prazosin/pharmacology, Rats, Rats, Inbred F344, Receptor, Epidermal Growth Factor, Receptors, Cell Surface/metabolism, Yohimbine/pharmacology
Pubmed
Web of science
Création de la notice
24/01/2008 11:05
Dernière modification de la notice
20/08/2019 14:23
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