Article: article from journal or magazin.
Norepinephrine decreases EGF binding in primary rat hepatocyte cultures.
Journal of Cellular Physiology
Norepinephrine (NE) produced a dose-dependent inhibition of 125I-epidermal growth factor (EGF) binding to adult rat hepatocytes in primary culture. This effect was maximal after 1 hr of incubation with NE and could be blocked by the presence of an alpha 1-specific adrenergic receptor antagonist. The inhibition of binding correlates with the ability of NE to enhance hepatocyte DNA synthesis in the presence of EGF and appears to be mediated by a reduction in EGF receptor number, without a significant change in receptor affinity.
Animals, Cells, Cultured, DNA/biosynthesis, Epidermal Growth Factor/metabolism, Female, Liver/cytology, Liver/drug effects, Norepinephrine/pharmacology, Pindolol/pharmacology, Prazosin/pharmacology, Rats, Rats, Inbred F344, Receptor, Epidermal Growth Factor, Receptors, Cell Surface/metabolism, Yohimbine/pharmacology
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