Long-term outcomes of pandemic 2009 influenza A(H1N1)-associated severe ARDS.
Details
Serval ID
serval:BIB_681662501E59
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Long-term outcomes of pandemic 2009 influenza A(H1N1)-associated severe ARDS.
Journal
Chest
Working group(s)
REVA Study Group
Contributor(s)
Cadiergue V., Just B., Papazian L., du Cheyron D., Charbonneau P., Guivarch G., Capellier G., Tonnelier JM., Boles JM., Riu B., Youssef J., Gabinski C., Le Tulzo Y., Garot D., Mercier E., Ara-Somohano C., Timsit JF., Villers D., Boulain T., Mercat A., Tatopoulos A., Bollaert PE., Ait Hssain A., Badia P., Kuteifan K., Guiot P., Guérin C., Rosseli S., Luyt CE., Combes A., Chastre J., Lemiale V., Azoulay E., Schlemmer B., Guidet B., Charpentier J., Mira JP., Mourvilliers B., Wolff M., Fartoukh M., Beduneau G., Richard JC., Lagarigue MH., Bedos JP., Zogheib E., Dupont H., Reignier J., Robert R., Clavel M., Osman D., Richard C., Richecoeur J., Charbit B., Ciuchette A., Funck-Bretano C., Laine F., Duale C., Bardou M., Delplanque D., Jozefovicz E., Lamotte C., Libersa C., Clavel M., Lesavre N., Bernard JP., Morange S., Robert R., Thalamas C., Galitzki-Gerber M., Calvas F., Beduneau G., Weber J., Cailleux A., Bernard L., Girodet PO., Pariente A.
ISSN
1931-3543 (Electronic)
ISSN-L
0012-3692
Publication state
Published
Issued date
2012
Peer-reviewed
Oui
Volume
142
Number
3
Pages
583-592
Language
english
Notes
Publication types: Journal Article ; Multicenter Study ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Publication Status: ppublish
Abstract
BACKGROUND: No data on long-term outcomes of survivors of 2009 influenza A(H1N1) (A[H1N1])-associated ARDS are available. The objective of this study was to compare the 1-year outcomes of survivors of A(H1N1)-associated ARDS, according to use or no use of extracorporeal lung assist (ECLA), using its need as an ARDS severity surrogate.
METHODS: Survivors of ARDS (12 with ECLA use vs 25 without, corresponding to 75% and 54% of the eligible patients for each group, respectively) selected from the Réseau Européen de Ventilation Artificielle (REVA) registry had previously been healthy, with only pregnancy and/or moderate obesity (BMI ≤ 35 kg/m²) as known risk factors for A(H1N1) infection. Lung function and morphology, health-related quality of life (HRQoL), and psychologic impairment were evaluated.
RESULTS: At 1 year post-ICU discharge for the ECLA and no-ECLA groups, respectively, 50% and 40% reported significant exertion dyspnea, 83% and 64% had returned to work, and 75% and 64% had decreased diffusion capacity across the blood-gas barrier, despite their near-normal and similar lung function test results. For both groups, exercise test results showed diminished but comparable exercise capacities, with similar alveolar-arterial oxygen gradients at peak exercise, and CT scans showed minor abnormal findings. HRQoL assessed by the 36-Item Short-Form Health Survey was poorer for both groups than for a sex- and age-matched general population group, but without between-group differences. ECLA and no-ECLA group patients, respectively, had symptoms of anxiety (50% and 56%) and depression (28% and 28%) and were at risk for posttraumatic stress disorder (41% and 44%).
CONCLUSIONS: One year post-ICU discharge, a majority of survivors of A(H1N1)-associated ARDS had minor lung disabilities with diminished diffusion capacities across the blood-gas barrier, and most had psychologic impairment and poorer HRQoL than a sex- and age-matched general population group. ECLA and no-ECLA group patients had comparable outcomes.
TRIAL REGISTRY: ClinicalTrials.gov; No.: NCT01271842; URL: www.clinicaltrials.gov
METHODS: Survivors of ARDS (12 with ECLA use vs 25 without, corresponding to 75% and 54% of the eligible patients for each group, respectively) selected from the Réseau Européen de Ventilation Artificielle (REVA) registry had previously been healthy, with only pregnancy and/or moderate obesity (BMI ≤ 35 kg/m²) as known risk factors for A(H1N1) infection. Lung function and morphology, health-related quality of life (HRQoL), and psychologic impairment were evaluated.
RESULTS: At 1 year post-ICU discharge for the ECLA and no-ECLA groups, respectively, 50% and 40% reported significant exertion dyspnea, 83% and 64% had returned to work, and 75% and 64% had decreased diffusion capacity across the blood-gas barrier, despite their near-normal and similar lung function test results. For both groups, exercise test results showed diminished but comparable exercise capacities, with similar alveolar-arterial oxygen gradients at peak exercise, and CT scans showed minor abnormal findings. HRQoL assessed by the 36-Item Short-Form Health Survey was poorer for both groups than for a sex- and age-matched general population group, but without between-group differences. ECLA and no-ECLA group patients, respectively, had symptoms of anxiety (50% and 56%) and depression (28% and 28%) and were at risk for posttraumatic stress disorder (41% and 44%).
CONCLUSIONS: One year post-ICU discharge, a majority of survivors of A(H1N1)-associated ARDS had minor lung disabilities with diminished diffusion capacities across the blood-gas barrier, and most had psychologic impairment and poorer HRQoL than a sex- and age-matched general population group. ECLA and no-ECLA group patients had comparable outcomes.
TRIAL REGISTRY: ClinicalTrials.gov; No.: NCT01271842; URL: www.clinicaltrials.gov
Keywords
Adult, Anxiety/epidemiology, Anxiety/psychology, Case-Control Studies, Depression/epidemiology, Depression/psychology, France/epidemiology, Humans, Incidence, Influenza A Virus, H1N1 Subtype, Influenza, Human/complications, Influenza, Human/epidemiology, Longitudinal Studies, Lung/physiopathology, Lung/radiography, Male, Middle Aged, Outcome Assessment (Health Care), Pandemics, Prospective Studies, Quality of Life/psychology, Registries, Respiratory Distress Syndrome, Adult/etiology, Respiratory Distress Syndrome, Adult/psychology, Respiratory Function Tests, Respiratory Therapy/methods, Retrospective Studies, Steroids/therapeutic use, Tomography, X-Ray Computed, Treatment Outcome
Pubmed
Web of science
Create date
28/03/2012 14:23
Last modification date
20/08/2019 15:23
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