Endoplasmic reticulum calcium pumps and cancer cell differentiation.

Details

Serval ID
serval:BIB_67691497160B
Type
Article: article from journal or magazin.
Collection
Publications
Title
Endoplasmic reticulum calcium pumps and cancer cell differentiation.
Journal
Biomolecules
Author(s)
Papp B., Brouland J.P., Arbabian A., Gélébart P., Kovács T., Bobe R., Enouf J., Varin-Blank N., Apáti A.
ISSN
2218-273X (Electronic)
ISSN-L
2218-273X
Publication state
Published
Issued date
2012
Peer-reviewed
Oui
Volume
2
Number
1
Pages
165-186
Language
english
Notes
Publication types: Journal ArticlePublication Status: epublish
Abstract
The endoplasmic reticulum (ER) is a major intracellular calcium storage pool and a multifunctional organelle that accomplishes several calcium-dependent functions involved in many homeostatic and signaling mechanisms. Calcium is accumulated in the ER by Sarco/Endoplasmic Reticulum Calcium ATPase (SERCA)-type calcium pumps. SERCA activity can determine ER calcium content available for intra-ER functions and for calcium release into the cytosol, and can shape the spatiotemporal characteristics of calcium signals. SERCA function therefore constitutes an important nodal point in the regulation of cellular calcium homeostasis and signaling, and can exert important effects on cell growth, differentiation and survival. In several cell types such as cells of hematopoietic origin, mammary, gastric and colonic epithelium, SERCA2 and SERCA3-type calcium pumps are simultaneously expressed, and SERCA3 expression levels undergo significant changes during cell differentiation, activation or immortalization. In addition, SERCA3 expression is decreased or lost in several tumor types when compared to the corresponding normal tissue. These observations indicate that ER calcium homeostasis is remodeled during cell differentiation, and may present defects due to decreased SERCA3 expression in tumors. Modulation of the state of differentiation of the ER reflected by SERCA3 expression constitutes an interesting new aspect of cell differentiation and tumor biology.
Pubmed
Open Access
Yes
Create date
13/10/2015 10:13
Last modification date
20/08/2019 14:22
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