Article: article d'un périodique ou d'un magazine.
T cell costimulation by the TNF ligand BAFF.
Journal of Immunology
Date de publication
The TNF ligand family member BAFF (B cell activating factor belonging to the TNF family, also called Blys, TALL-1, zTNF-4, or THANK) is an important survival factor for B cells [corrected]. In this study, we show that BAFF is able to regulate T cell activation. rBAFF induced responses (thymidine incorporation and cytokine secretion) of T cells, suboptimally stimulated through their TCR. BAFF activity was observed on naive, as well as on effector/memory T cells (both CD4+ and CD8+ subsets), indicating that BAFF has a wide function on T cell responses. Analysis of the signal transduced by BAFF into T cells shows that BAFF has no obvious effect on T cell survival upon activation, but is able to deliver a complete costimulation signal into T cells. Indeed, BAFF is sufficient to induce IL-2 secretion and T cell division, when added to an anti-TCR stimulation. This highlights some differences in the BAFF signaling pathway in T and B cells. In conclusion, our results indicate that BAFF may play a role in the development of T cell responses, in addition to its role in B cell homeostasis.
B-Cell Activating Factor, Cell Division/immunology, Cells, Cultured, Cytokines/secretion, Flow Cytometry, Humans, Immunologic Memory, Interleukin-2/physiology, Interphase/immunology, Ligands, Lymphocyte Activation/immunology, Membrane Proteins/metabolism, Membrane Proteins/physiology, Receptors, Antigen, T-Cell/physiology, Receptors, Tumor Necrosis Factor/metabolism, Receptors, Tumor Necrosis Factor/physiology, Signal Transduction/immunology, T-Lymphocyte Subsets/cytology, T-Lymphocyte Subsets/immunology, Thymidine/metabolism, Tumor Necrosis Factor-alpha/metabolism, Tumor Necrosis Factor-alpha/physiology
Web of science
Création de la notice
Dernière modification de la notice