Article: article from journal or magazin.
T cell costimulation by the TNF ligand BAFF.
Journal of Immunology
The TNF ligand family member BAFF (B cell activating factor belonging to the TNF family, also called Blys, TALL-1, zTNF-4, or THANK) is an important survival factor for B cells [corrected]. In this study, we show that BAFF is able to regulate T cell activation. rBAFF induced responses (thymidine incorporation and cytokine secretion) of T cells, suboptimally stimulated through their TCR. BAFF activity was observed on naive, as well as on effector/memory T cells (both CD4+ and CD8+ subsets), indicating that BAFF has a wide function on T cell responses. Analysis of the signal transduced by BAFF into T cells shows that BAFF has no obvious effect on T cell survival upon activation, but is able to deliver a complete costimulation signal into T cells. Indeed, BAFF is sufficient to induce IL-2 secretion and T cell division, when added to an anti-TCR stimulation. This highlights some differences in the BAFF signaling pathway in T and B cells. In conclusion, our results indicate that BAFF may play a role in the development of T cell responses, in addition to its role in B cell homeostasis.
B-Cell Activating Factor, Cell Division/immunology, Cells, Cultured, Cytokines/secretion, Flow Cytometry, Humans, Immunologic Memory, Interleukin-2/physiology, Interphase/immunology, Ligands, Lymphocyte Activation/immunology, Membrane Proteins/metabolism, Membrane Proteins/physiology, Receptors, Antigen, T-Cell/physiology, Receptors, Tumor Necrosis Factor/metabolism, Receptors, Tumor Necrosis Factor/physiology, Signal Transduction/immunology, T-Lymphocyte Subsets/cytology, T-Lymphocyte Subsets/immunology, Thymidine/metabolism, Tumor Necrosis Factor-alpha/metabolism, Tumor Necrosis Factor-alpha/physiology
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