Accelerated versus conventional corneal crosslinking for refractive instability: an update.

Details

Serval ID
serval:BIB_65AF65A6C634
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Accelerated versus conventional corneal crosslinking for refractive instability: an update.
Journal
Current opinion in ophthalmology
Author(s)
Kymionis G.D., Kontadakis G.A., Hashemi K.K.
ISSN
1531-7021 (Electronic)
ISSN-L
1040-8738
Publication state
Published
Issued date
07/2017
Peer-reviewed
Oui
Volume
28
Number
4
Pages
343-347
Language
english
Notes
Publication types: Journal Article ; Review
Publication Status: ppublish
Abstract
Corneal crosslinking (CXL) is a relatively new treatment modality offering refractive stability in patients with ectatic disorders. The procedure as initially described (Dresden protocol) is time consuming; accelerated protocols have been lately developed. The purpose of this review is to present the recent findings regarding the comparison of accelerated CXL with the conventional Dresden protocol.
A variety of accelerated protocols are described in the literature. Safety and efficacy of the procedures with regard to stability seem to be equivalent in initial studies but indirect measures of efficacy, such as demarcation line depth and laboratory measurements, do not always confirm equivalence of accelerated protocols in comparison to conventional one. Modified accelerated protocols must be developed in order to overcome this.
Accelerated CXL protocols seem to be a valid alternative to the conventional protocol; however, more comparative long term studies are needed to confirm the validity and to elucidate which accelerated protocol is ideal in each case.

Keywords
Clinical Protocols, Clinical Studies as Topic, Collagen/metabolism, Corneal Stroma/metabolism, Cross-Linking Reagents/therapeutic use, Humans, Keratoconus/drug therapy, Keratoconus/metabolism, Keratoconus/pathology, Photochemotherapy/methods, Photosensitizing Agents/therapeutic use, Riboflavin/therapeutic use, Tomography, Optical Coherence, Ultraviolet Rays, Visual Acuity
Pubmed
Web of science
Create date
27/06/2017 17:07
Last modification date
20/08/2019 14:21
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