Article: article from journal or magazin.
Developmentally regulated extinction of Ly-49 receptor expression permits maturation and selection of NK1.1+ T cells.
The Journal of Experimental Medicine
Publication types: Journal Article ; Research Support, Non-U.S. Gov't Publication Status: ppublish
Clonally distributed inhibitory receptors negatively regulate natural killer (NK) cell function via specific interactions with allelic forms of major histocompatibility complex (MHC) class I molecules. In the mouse, the Ly-49 family of inhibitory receptors is found not only on NK cells but also on a minor (NK1.1+) T cell subset. Using Ly-49 transgenic mice, we show here that the development of NK1.1+ T cells, in contrast to NK or conventional T cells, is impaired when their Ly-49 receptors engage self-MHC class I molecules. Impaired NK1.1+ T cell development in transgenic mice is associated with a failure to select the appropriate CD1-reactive T cell receptor repertoire. In normal mice, NK1.1+ T cell maturation is accompanied by extinction of Ly-49 receptor expression. Collectively, our data imply that developmentally regulated extinction of inhibitory MHC-specific receptors is required for normal NK1.1+ T cell maturation and selection.
Animals, Antigens/biosynthesis, Antigens, Ly, Antigens, Surface, Cell Differentiation, Flow Cytometry, Killer Cells, Natural/cytology, Killer Cells, Natural/immunology, Lectins, C-Type, Liver/cytology, Liver/immunology, Membrane Glycoproteins/biosynthesis, Membrane Glycoproteins/genetics, Mice, Mice, Transgenic, NK Cell Lectin-Like Receptor Subfamily B, Protein Biosynthesis, Proteins, Receptors, Antigen, T-Cell, Receptors, Immunologic/biosynthesis, Receptors, NK Cell Lectin-Like, Selection, Genetic, T-Lymphocyte Subsets/cytology, T-Lymphocyte Subsets/immunology, Thymus Gland/cytology, Thymus Gland/immunology
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