Thyroglobulin levels and thyroglobulin doubling time independently predict a positive 18F-FDG PET/CT scan in patients with biochemical recurrence of differentiated thyroid carcinoma.

Details

Serval ID
serval:BIB_646CEC1B8D95
Type
Article: article from journal or magazin.
Collection
Publications
Title
Thyroglobulin levels and thyroglobulin doubling time independently predict a positive 18F-FDG PET/CT scan in patients with biochemical recurrence of differentiated thyroid carcinoma.
Journal
European journal of nuclear medicine and molecular imaging
Author(s)
Giovanella L., Trimboli P., Verburg F.A., Treglia G., Piccardo A., Foppiani L., Ceriani L.
ISSN
1619-7089 (Electronic)
ISSN-L
1619-7070
Publication state
Published
Issued date
06/2013
Peer-reviewed
Oui
Volume
40
Number
6
Pages
874-880
Language
english
Notes
Publication types: Journal Article
Publication Status: ppublish
Abstract
To assess the relationship between serum thyroglobulin (Tg) levels, Tg doubling time (Tg-DT) and the diagnostic performance of (18)F-FDG PET/CT in detecting recurrences of (131)I-negative differentiated thyroid carcinoma (DTC).
Included in the present study were 102 patients with DTC. All patients were treated by thyroid ablation (e.g. thyroidectomy and (131)I), and underwent (18)F-FDG PET/CT due to detectable Tg levels and negative conventional imaging. Consecutive serum Tg measurements performed before the (18)F-FDG PET/CT examination were used for Tg-DT calculation. The (18)F-FDG PET/CT results were assessed as true or false after histological and/or clinical follow-up.
Serum Tg levels were higher in patients with a positive (18)F-FDG PET/CT scan (median 6.7 ng/mL, range 0.7-73.6 ng/mL) than in patients with a negative scan (median 1.8 ng/mL, range 0.5-4.9 ng/mL; P < 0.001). In 43 (88 %) of 49 patients with a true-positive (18)F-FDG PET/CT scan, the Tg levels were >5.5 ng/mL, and in 31 (74 %) of 42 patients with a true-negative (18)F-FDG PET/CT scan, the Tg levels were ≤5.5 ng/mL. A Tg-DT of <1 year was found in 46 of 49 patients (94 %) with a true-positive (18)F-FDG PET/CT scan, and 40 of 42 patients (95 %) with a true-negative scan had a stable or increased Tg-DT. Moreover, combining Tg levels and Tg-DT as selection criteria correctly distinguished between patients with a positive and a negative scan (P<0.0001).
The accuracy of (18)F-FDG PET/CT significantly improves when the serum Tg level is above 5.5 ng/mL during levothyroxine treatment or when the Tg-DT is less than 1 year, independent of the absolute value.

Keywords
Adolescent, Adult, Aged, Cost-Benefit Analysis, Female, Fluorodeoxyglucose F18/pharmacology, Follow-Up Studies, Humans, Iodine Radioisotopes/pharmacology, Lung Neoplasms/pathology, Male, Middle Aged, Multimodal Imaging, Neoplasm Metastasis, Predictive Value of Tests, Radiopharmaceuticals/pharmacology, Recurrence, Sensitivity and Specificity, Thyroglobulin/metabolism, Thyroid Neoplasms/pathology, Thyroxine/pharmacology, Time Factors
Pubmed
Web of science
Create date
20/08/2017 20:02
Last modification date
20/08/2019 14:20
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